Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro

Grice, Jeffrey E., Ciotti, Susan, Weiner, Norman, Lockwood, Peter, Cross, Sheree E. and Roberts, Michael S. (2010) Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. Journal of Pharmaceutical Sciences, 99 2: 712-718. doi:10.1002/jps.21856


Author Grice, Jeffrey E.
Ciotti, Susan
Weiner, Norman
Lockwood, Peter
Cross, Sheree E.
Roberts, Michael S.
Title Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro
Journal name Journal of Pharmaceutical Sciences   Check publisher's open access policy
ISSN 0022-3549
Publication date 2010-02
Year available 2009
Sub-type Article (original research)
DOI 10.1002/jps.21856
Volume 99
Issue 2
Start page 712
End page 718
Total pages 7
Editor Ronald T. Borchardt
Place of publication United States
Publisher John Wiley & Sons
Collection year 2010
Language eng
Subject 920117 Skin and Related Disorders
111502 Clinical Pharmacology and Therapeutics
Formatted abstract
We examined uptake of the model therapeutic agent, minoxidil, into appendages, stratum corneum (SC), and through human skin, under the influence of different vehicles. Quantitative estimation of therapeutic drug deposition into all three areas has not previously been reported. Finite doses of minoxidil (2%, w/v) in formulations containing varying amounts of ethanol, propylene glycol (PG), and water (60:20:20, 80:20:0, and 0:80:20 by volume, respectively) were used. Minoxidil in SC (by tape stripping), appendages (by cyanoacrylate casting), and receptor fluid was determined by liquid scintillation counting. At early times (30 min, 2 h), ethanol-containing formulations (60:20:20 and 80:20:0) caused significantly greater minoxidil retention in SC and appendages, compared to the formulation lacking ethanol (0:80:20). A significant increase in minoxidil receptor penetration occurred with the PG-rich 0:80:20 formulation after 12 h. We showed that deposition of minoxidil into appendages, SC, and skin penetration into receptor fluid were similar in magnitude. Transport by the appendageal route is likely to be a key determinant of hair growth promotion by minoxidil. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:712-718, 2010
Keyword Absorption
Formulation vehicle
Membrane transport
Passive diffusion
Skin
Transdermal drug delivery
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Sun, 21 Feb 2010, 00:03:12 EST