MULCh: modules for the analysis of small-angle neutron contrast variation data from biomolecular assemblies

Whitten, Andrew E., Cai, Shuzhi and Trewhella, Jill (2008) MULCh: modules for the analysis of small-angle neutron contrast variation data from biomolecular assemblies. Journal of Applied Crystallography, 41 1: 222-226. doi:10.1107/S0021889807055136

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Author Whitten, Andrew E.
Cai, Shuzhi
Trewhella, Jill
Title MULCh: modules for the analysis of small-angle neutron contrast variation data from biomolecular assemblies
Formatted title
MULCh: modules for the analysis of small-angle neutron contrast variation data from biomolecular assemblies
Journal name Journal of Applied Crystallography   Check publisher's open access policy
ISSN 0021-8898
1600-5767
Publication date 2008-02
Sub-type Article (original research)
DOI 10.1107/S0021889807055136
Open Access Status File (Publisher version)
Volume 41
Issue 1
Start page 222
End page 226
Total pages 5
Place of publication Germany
Publisher Blackwell Munksgaard
Language eng
Formatted abstract
Small-angle neutron scattering with contrast variation can fill important gaps in our understanding of biomolecular assemblies, providing constraints that can aid in the construction of molecular models and in subsequent model refinements. This paper describes the implementation of simple tools for analysing neutron contrast variation data, accessible via a user-friendly web-based interface (http://www.mmb.usyd.edu.au/NCVWeb/). There are three modules accessible from the website to analyse neutron contrast variation data from bimolecular complexes. The first module, Contrast, computes neutron contrasts of each component of the complex required by the other two modules; the second module, Rg, analyses the contrast dependence of the radii of gyration to yield information relating to the size and disposition of each component in the complex; and the third, Compost, decomposes the contrast variation series into composite scattering functions, which contain information regarding the shape of each component of the complex, and their orientation with respect to each other.
Keyword Small-angle scattering
Neutron contrast variation
Biomolecular complexes
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 19 Feb 2010, 15:11:46 EST by Sue Green on behalf of Institute for Molecular Bioscience