Population screening for colorectal cancer: The implications of an ageing population

Macafee, D. A. L., Waller, M., Whynes, D. K., Moss, S. and Scholefield, J. H. (2008) Population screening for colorectal cancer: The implications of an ageing population. British Journal of Cancer, 99 12: 1991-2000. doi:10.1038/sj.bjc.6604788

Author Macafee, D. A. L.
Waller, M.
Whynes, D. K.
Moss, S.
Scholefield, J. H.
Title Population screening for colorectal cancer: The implications of an ageing population
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
Publication date 2008-12-16
Year available 2008
Sub-type Article (original research)
DOI 10.1038/sj.bjc.6604788
Open Access Status DOI
Volume 99
Issue 12
Start page 1991
End page 2000
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Population screening for colorectal cancer (CRC) has recently commenced in the United Kingdom supported by the evidence of a number of randomised trials and pilot studies. Certain factors are known to influence screening cost-effectiveness (e.g. compliance), but it remains unclear whether an ageing population (i.e. demographic change) might also have an effect. The aim of this study was to simulate a population-based screening setting using a Markov model and assess the effect of increasing life expectancy on CRC screening cost-effectiveness. A Markov model was constructed that aimed, using a cohort simulation, to estimate the cost effectiveness of CRC screening in an England and Wales population for two timescales: 2003 (early cohort) and 2033 (late cohort). Four model outcomes were calculated; screened and non-screened cohorts in 2003 and 2033. The screened cohort of men and women aged 60 years were offered biennial unhydrated faecal occult blood testing until the age of 69 years. Life expectancy was assumed to increase by 2.5 years per decade. There were 407 552 fewer people entering the model in the 2033 model due to a lower birth cohort, and population screening saw 30 345 fewer CRC-related deaths over the 50 years of the model. Screening the 2033 cohort cost d96 million with cost savings of d43 million in terms of detection and treatment and d28 million in palliative care costs. After 30 years of follow-up, the cost per life year saved was d1544. An identical screening programme in an early cohort (2003)saw a cost per life year saved of d1651. Population screening for CRC is costly but enables cost savings in certain areas and a considerable reduction in mortality from CRC. This Markov simulation suggests that the cost-effectiveness of population screening for CRC in the United Kingdom may actually be improved by rising life expectancies. © 2008 Cancer Research UK
Keyword Colorectal Cancer
Life Expectancy
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Centre for Military and Veterans' Health Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 18 Feb 2010, 09:22:29 EST by Christine Ouslinis on behalf of Faculty Of Health Sciences