Acute intentional self-poisoning with a herbicide product containing fenoxaprop-P-ethyl, ethoxysulfuron, and isoxadifen ethyl: a prospective observational study

Zawahir, S., Roberts, D. M., Palangasinghe, C., Mohamed, F., Eddleston, M., Dawson, A. H., Buckley, N. A., Ren, L. L., Medley, G. A. and Gawarammana, I. (2009) Acute intentional self-poisoning with a herbicide product containing fenoxaprop-P-ethyl, ethoxysulfuron, and isoxadifen ethyl: a prospective observational study. CLINICAL TOXICOLOGY, 47 8: 792-797.


Author Zawahir, S.
Roberts, D. M.
Palangasinghe, C.
Mohamed, F.
Eddleston, M.
Dawson, A. H.
Buckley, N. A.
Ren, L. L.
Medley, G. A.
Gawarammana, I.
Title Acute intentional self-poisoning with a herbicide product containing fenoxaprop-P-ethyl, ethoxysulfuron, and isoxadifen ethyl: a prospective observational study
Journal name CLINICAL TOXICOLOGY  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2009
Sub-type Article
Year available 2009
DOI 10.1080/15563650903174810
Volume number 47
Issue number 8
ISSN 1556-3650
Start page 792
End page 797
Total pages 6
Editor McGuigen, M. A.
Place of publication United States
Publisher Informa Healthcare
Collection year 2010
Language eng
Subject C1
920204 Evaluation of Health Outcomes
110103 Medical Biochemistry: Inorganic Elements and Compounds
Abstract Background. Herbicides are commonly ingested for self-harm, but relatively little has been published on poisoning with herbicides other than paraquat and glyphosate. We report here a case series of patients with acute exposure to a combination herbicide (brand name Tiller Gold or Whip Super) containing the selective phenoxy herbicide compounds fenoxaprop-P-ethyl and ethoxysulfuron and a safener isoxadifen ethyl. Method. Clinical data on all patients presenting with Tiller Gold or Whip Super poisoning to two General Hospitals in Sri Lanka from 2002-2008 were collected prospectively until discharge. Results. Eighty-six patients with a history of Tiller Gold or Whip Super ingestion were included. The main clinical features were an epigastric burning sensation and vomiting; however, most of those who vomited had received gastric lavage or forced emesis. Eight patients had a reduced level of consciousness on admission (Glasgow coma scale 9-14) that resolved without intervention over several hours. Only symptomatic and supportive care was required. The median hospital stay was 1 day (IQR: 1-2) and the case fatality was zero (95% confidence interval: 0-4.2%). This low case fatality compared favorably with the case fatality of other common herbicides in our cohort: paraquat >40%, propanil >10%, 4-chloro-2-methylphenoxyacetic acid > 5%, and glyphosate >2%. Conclusion. This combination herbicide product appears to be safe in patients with acute self-poisoning, particularly in comparison with other herbicides, and causing few clinical features
Keyword Fenoxaprop-P-ethyl
Gastric lavage
Tiller Gold
Acute self-poisoning
Sri Lanka
DEVELOPING-WORLD
SRI-LANKA
PESTICIDES
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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