Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-gamma Production

Mattarollo, Stephen R., Rahimpour, Azad, Choyce, Allison, Godfrey, Dale I., Leggatt, Graham R. and Frazer, Ian H. (2010) Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-gamma Production. Journal of Immunology, 184 3: 1242-1250. doi:10.4049/jimmunol.0902191


Author Mattarollo, Stephen R.
Rahimpour, Azad
Choyce, Allison
Godfrey, Dale I.
Leggatt, Graham R.
Frazer, Ian H.
Title Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-gamma Production
Formatted title
Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-γ Production
Journal name Journal of Immunology   Check publisher's open access policy
ISSN 0022-1767
1550-6606
Publication date 2010-02
Year available 2009
Sub-type Article (original research)
DOI 10.4049/jimmunol.0902191
Volume 184
Issue 3
Start page 1242
End page 1250
Total pages 9
Place of publication Bethesda, MD, United States
Publisher American Association of Immunologists
Collection year 2010
Language eng
Subject 970106 Expanding Knowledge in the Biological Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
920102 Cancer and Related Disorders
920108 Immune System and Allergy
1107 Immunology
1112 Oncology and Carcinogenesis
Abstract NKT cells can promote or inhibit adaptive immune responses. Cutaneous immunity is tightly regulated by cooperation between innate and adaptive immune processes, but the role of NKT cells in regulating cutaneous immunity is largely unknown. In this study, we show, in a mouse model, that skin-infiltrating CD1d-restricted NKT cells in HPV16-E7 transgenic hyperplastic skin produce IFN-gamma, which can prevent rejection of HPV16-E7-expressing skin grafts. Suppression of graft rejection is associated with the accumulation of CD1d(hi)-expressing CD11c(+)F4/80(hi) myeloid cells in hyperplastic skin. Blockade of CD1d, removal of NKT cells, or local inhibition of IFN-gamma signaling is sufficient to restore immune-mediated graft rejection. Thus, inhibition of NKT cell recruitment or function may enable effective immunity against tumor and viral Ags expressed in epithelial cells.
Keyword Killer T-cells
Nonobese diabetic mice
Alpha-galactosylceramide
Regulatory cells
Autoimmune encephalomyelitis
Tumor-immunity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sun, 14 Feb 2010, 00:01:37 EST