Progression of diastolic dysfunction in type II diabetes is associated with blood pressure, weight gain and increasing LV mass

Hare, J. L., Leano, R., Jeffries, L., Downey, M., Hordern, M. and Marwick, T. H. (2008). Progression of diastolic dysfunction in type II diabetes is associated with blood pressure, weight gain and increasing LV mass. In: European Heart Journal. Abstracts of: European Society of Cardiology Congress 2008. European Society of Cardiology Congress 2008, Munich, Germany, (382-383). 30 August-3 September 2008. doi:10.1093/eurheartj/ehn375


Author Hare, J. L.
Leano, R.
Jeffries, L.
Downey, M.
Hordern, M.
Marwick, T. H.
Title of paper Progression of diastolic dysfunction in type II diabetes is associated with blood pressure, weight gain and increasing LV mass
Conference name European Society of Cardiology Congress 2008
Conference location Munich, Germany
Conference dates 30 August-3 September 2008
Proceedings title European Heart Journal. Abstracts of: European Society of Cardiology Congress 2008   Check publisher's open access policy
Place of Publication London, U. K.
Publisher Oxford University Press
Publication Year 2008
Sub-type Published abstract
DOI 10.1093/eurheartj/ehn375
ISSN 1520-765X
1554-2815
Volume 29
Issue Supplement 1
Start page 382
End page 383
Total pages 2
Language eng
Formatted Abstract/Summary
Background: Type 2 diabetes mellitus (T2DM) is associated with subclinical diastolic
dysfunction (DD), but the evolution of these changes is undefined. We
investigated the progression and clinical correlates of DD in T2DM.
Methods: 159 prospectively recruited T2DM pts (age 55±10 yrs, 45% male) underwent
2D echocardiography, metabolic and clinical evaluation at baseline and
1 year. Diastolic function was characterized as normal, delayed relaxation pattern,
pseudonormal or restrictive. Change in diastolic categorization and tissue
Doppler Em was assessed, and correlations sought with clinical and metabolic
variables using multivariate logistic regression.
Results: At baseline, 104 pts (65%) had normal diastolic function, 43 pts (27%) had delayed relaxation, 11 (7%) were pseudonormal and 1 (0.6%) was restrictive.
At 1 year, 50% were unchanged, 26% had progressed and 24% improved; see
Table for correlates of deterioration. Change in Em was independently correlated
with age (p<0.02), duration of diabetes (p<0.01) and change in waist circumference
(p<0.02). Correlates of deterioration in diastolic category were baseline
systolic blood pressure (SBP) (p<0.02), change in weight (p<0.05) and change
in LV mass index (p<0.02). There were no significant associations with glucose
levels, HbA1C, lipids, VO2max or other clinical parameters.
Conclusions: Abnormal diastolic function is common in T2DM and progression
is independently associated with higher baseline SBP, weight gain and increasing
LV mass.
Subjects 1102 Cardiovascular Medicine and Haematology
110201 Cardiology (incl. Cardiovascular Diseases)
110306 Endocrinology
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Thu, 11 Feb 2010, 12:17:44 EST by Jon Swabey on behalf of Faculty Of Health Sciences