Eph, a protein family coming of age: More confusion, insight, or complexity?

Lackmann, Martin and Boyd, Andrew W. (2008) Eph, a protein family coming of age: More confusion, insight, or complexity?. Science Signaling, 1 15: 1-16. doi:10.1126/stke.115re2


Author Lackmann, Martin
Boyd, Andrew W.
Title Eph, a protein family coming of age: More confusion, insight, or complexity?
Journal name Science Signaling   Check publisher's open access policy
ISSN 1937-9145
1945-0877
Publication date 2008-04-15
Sub-type Article (original research)
DOI 10.1126/stke.115re2
Volume 1
Issue 15
Start page 1
End page 16
Total pages 16
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Subject 1109 Neurosciences
Abstract Since the mid-1980s, Eph receptors have evolved from being regarded as orphan receptors with unknown functions and ligands to becoming one of the most complex "global positioning systems" that regulates cell traffic in multicellular organisms. During this time, there has been an exponentially growing interest in Ephs and ephrin ligands, coinciding with important advances in the way biological function is interrogated through mapping of genomes and manipulation of genes. As a result, many of the original concepts that used to define Eph signaling and function went overboard. Clearly, the need for progress in understanding Eph-ephrin biology and the underlying molecular principles involved has been compelling. Many cell-positioning programs during normal and oncogenic development—in particular, the patterning of skeletal, vascular, and nervous systems—are modulated in some way by Eph-ephrin function. Undeniably, the complexity of the underlying signaling networks is considerable, and it seems probable that systems biology approaches are required to further improve our understanding of Eph function.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 88 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 10 Feb 2010, 14:01:27 EST by Christine Ouslinis on behalf of Queensland Brain Institute