Salivary and serum substance P, neurokinin A and calcitonin gene related peptide in burning mouth syndrome

Vucicevic-Boras, Vanja, Savage, Neil W., Brailo, Vlaho, Lukac, Josip, Lukac, Maja and Alajbeg, Iva Z. (2010) Salivary and serum substance P, neurokinin A and calcitonin gene related peptide in burning mouth syndrome. Medicina Oral Patologia Oral Cirugia Bucal, 15 3: e427-e431. doi:10.4317/medoral.15.e427


Author Vucicevic-Boras, Vanja
Savage, Neil W.
Brailo, Vlaho
Lukac, Josip
Lukac, Maja
Alajbeg, Iva Z.
Title Salivary and serum substance P, neurokinin A and calcitonin gene related peptide in burning mouth syndrome
Journal name Medicina Oral Patologia Oral Cirugia Bucal   Check publisher's open access policy
ISSN 1698-4447
1698-6946
Publication date 2010-05
Sub-type Article (original research)
DOI 10.4317/medoral.15.e427
Volume 15
Issue 3
Start page e427
End page e431
Total pages 5
Place of publication Valencia, Spain
Publisher Medicina Oral Sl
Collection year 2011
Language eng
Subject C1
920113 Oro-Dental Disorders
110505 Oral Medicine and Pathology
Formatted abstract
Background: Burning mouth syndrome (BMS) is an enigmatic condition with the etiopathogenesis remaining largely obscure. However, a neuropathic basis for BMS continues to be an area of active clinical and research interest.

Aim: It is becoming increasingly evident that certain oral disorders may be modulated by imbalances in certain neuropeptides such as substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) therefore we measured SP, NKA and CGRP in the saliva and sera of BMS patients as well as controls.

Subjects and Methods: Salivary and serum SP, NKA and CGRP were determined in the 26 female patients with burning mouth syndrome (age range 51-78, mean 65.69 yrs), and in the 22 female controls (age range 24-82, mean 49.72 yrs). Serum and salivary SP, NKA, CGRP levels were determined by commercial competitive enzyme immunoassay kits. Statistical analysis was performed by use of descriptive statistics and analysis of variance.

Results and Conclusions: No significant differences in salivary SP, NKA and CGRP as well as serum SP and CGRP between BMS patients and controls could be found. However, significantly decreased serum neurokinin A (p<0.05) in BMS patients may reflect an inefficient dopaminergic system.
© Medicina Oral S.L.
Keyword Substance P
Neurokinin A
Calcitonin gene-related peptide
Burning mouth syndrome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Dentistry Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 09 Feb 2010, 13:57:56 EST by Margot Dallinger on behalf of School of Dentistry