Non-coding RNAs: regulators of disease

Taft, R. J., Pang, K. C., Mercer, T. R., Dinger, M and Mattick, J. S. (2009) Non-coding RNAs: regulators of disease. Journal of Pathology, 220 2: 126-139. doi:10.1002/path.2638


Author Taft, R. J.
Pang, K. C.
Mercer, T. R.
Dinger, M
Mattick, J. S.
Title Non-coding RNAs: regulators of disease
Journal name Journal of Pathology   Check publisher's open access policy
ISSN 0022-3417
Publication date 2009-10-30
Year available 2009
Sub-type Article (original research)
DOI 10.1002/path.2638
Volume 220
Issue 2
Start page 126
End page 139
Total pages 14
Editor Peter A Hall
Place of publication West Sussex, United Kingdom
Publisher John Wiley & Sons
Collection year 2010
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
110105 Medical Biochemistry: Nucleic Acids
Abstract For 50 years the term gene has been synonymous with regions of the genome encoding mRNAs that are translated into protein. However, recent genome-wide studies have shown that the human genome is pervasively transcribed and produces many thousands of regulatory non-protein-coding RNAs (ncRNAs), including microRNAs, small interfering RNAs, PIWI-interacting RNAs and various classes of long ncRNAs. It is now clear that these RNAs fulfil critical roles as transcriptional and post-transcriptional regulators and as guides of chromatin-modifying complexes. Here we review the biology of ncRNAs, focusing on the fundamental mechanisms by which ncRNAs facilitate normal development and physiology and, when dysfunctional, underpin disease. We also discuss evidence that intergenic regions associated with complex diseases express ncRNAs, as well as the potential use of ncRNAs as diagnostic markers and therapeutic targets. Taken together, these observations emphasize the need to move beyond the confines of protein-coding genes and highlight the fact that continued investigation of ncRNA biogenesis and function will be necessary for a comprehensive understanding of human disease. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Keyword non-coding RNAs
small RNAs
microRNAs
RNA interference
genome-wide association study
SMALL INTERFERING RNAS
DOUBLE-STRANDED-RNA
TRANSCRIPTION START SITES
EMBRYONAL CARCINOMA-CELLS
GENOME-WIDE ANALYSIS
LET-7 MICRORNA
GENE-EXPRESSION
CAENORHABDITIS-ELEGANS
CODING REGIONS
MESSENGER-RNA
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Created: Sun, 07 Feb 2010, 10:03:19 EST