Inflammatory lipid mediators in adipocyte function and obesity

Iyer, Abishek, Fairlie, David P., Prins, Johannes B., Hammock, Bruce D. and Brown, Lindsay (2010) Inflammatory lipid mediators in adipocyte function and obesity. Nature Reviews Endocrinology, 6 2: 71-82. doi:10.1038/nrendo.2009.264

Author Iyer, Abishek
Fairlie, David P.
Prins, Johannes B.
Hammock, Bruce D.
Brown, Lindsay
Title Inflammatory lipid mediators in adipocyte function and obesity
Journal name Nature Reviews Endocrinology   Check publisher's open access policy
ISSN 1759-5029
Publication date 2010-02
Sub-type Article (original research)
DOI 10.1038/nrendo.2009.264
Volume 6
Issue 2
Start page 71
End page 82
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2011
Language eng
Subject C1
920106 Endocrine Organs and Diseases (excl. Diabetes)
060104 Cell Metabolism
Abstract Survival of multicellular organisms depends on their ability to fight infection, metabolize nutrients, and store energy for times of need. Unsurprisingly, therefore, immunoregulatory and metabolic mechanisms interact in human conditions such as obesity. Both infiltrating immunoinflammatory cells and adipocytes play critical roles in the modulation of metabolic homeostasis, so it is important to understand factors that regulate both adipocyte and immune cell function. A currently favored paradigm for obesity-associated metabolic dysfunction is that chronic macronutrient and/or lipid overload (associated with adiposity) induces cellular stress that initiates and perpetuates an inflammatory cycle and pathophysiological signaling of immunoinflammatory cells and adipocytes. Many lipid mediators exert their biological effects by binding to cognate receptors, such as G-protein-coupled receptors and Toll-like receptors. This process is tightly regulated under normal physiological conditions, and any disruption can initiate disease processes. Observations that cellular lipid loading (associated with adiposity) initiates inflammatory events has encouraged studies on the role of lipid mediators. In this review, we speculate that lipid mediators act on important immune receptors to induce low-grade tissue inflammation, which leads to adipocyte and metabolic dysfunction. © 2010 Macmillan Publishers Limited. All rights reserved.
Keyword Soluble epoxide hydrolase
Adipose-tissue development
Induced Insulin-resistance
Oxygen species generation
Chemically-defined medium
Activated receptor-delta
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Sun, 07 Feb 2010, 00:01:24 EST