The effect of alcohol and nicotine abuse on gene expression in the brain

Flatscher-Bader, Traute and Wilce, Peter A. (2009) The effect of alcohol and nicotine abuse on gene expression in the brain. Nutrition Research Reviews, 22 2: 148-162. doi:10.1017/S0954422409990114

Author Flatscher-Bader, Traute
Wilce, Peter A.
Title The effect of alcohol and nicotine abuse on gene expression in the brain
Journal name Nutrition Research Reviews   Check publisher's open access policy
ISSN 0954-4224
Publication date 2009-11-10
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1017/S0954422409990114
Volume 22
Issue 2
Start page 148
End page 162
Total pages 15
Editor Kate Younger
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2010
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
111103 Nutritional Physiology
Abstract Alcohol intake at levels posing an acute heath risk is common amongst teenagers. Alcohol abuse is the second most common mental disorder worldwide. The incidence of smoking is decreasing in the Western world but increasing in developing countries and is the leading cause of preventable death worldwide. Considering the longstanding history of alcohol and tobacco consumption in human societies, it might be surprising that the molecular mechanisms underlying alcohol and smoking dependence are still incompletely understood. Effective treatments against the risk of relapse are lacking. Drugs of abuse exert their effect manipulating the dopaminergic mesocorticolimbic system. In this brain region, alcohol has many potential targets including membranes and several ion channels, while other drugs, for example nicotine, act via specific receptors or binding proteins. Repeated consumption of drugs of abuse mediates adaptive changes within this region, resulting in addiction. The high incidence of alcohol and nicotine co-abuse complicates analysis of the molecular basis of the disease. Gene expression profiling is a useful approach to explore novel drug targets in the brain. Several groups have utilised this technology to reveal drug-sensitive pathways in the mesocorticolimbic system of animal models and in human subjects. These studies are the focus of the present review.
Keyword Alcohol abuse
Nicotine abuse
Gene expression
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2010 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 07 Feb 2010, 00:01:17 EST