Circling the enemy: cyclic proteins in plant defence

Craik, David J. (2009) Circling the enemy: cyclic proteins in plant defence. Trends in Plant Science, 14 6: 328-335. doi:10.1016/j.tplants.2009.03.003

Author Craik, David J.
Title Circling the enemy: cyclic proteins in plant defence
Journal name Trends in Plant Science   Check publisher's open access policy
ISSN 1360-1385
Publication date 2009-06
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.tplants.2009.03.003
Volume 14
Issue 6
Start page 328
End page 335
Total pages 8
Editor Susanne C. Brink
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2010
Language eng
Subject C1
97 Expanding Knowledge
970106 Expanding Knowledge in the Biological Sciences
0607 Plant Biology
060799 Plant Biology not elsewhere classified
Abstract Cyclotides are ultra-stable plant proteins that have a circular peptide backbone crosslinked by a cystine knot of disulfide bonds. They are produced in large quantities by plants of the Violaceae and Rubiaceae families and have a role in plant defence against insect predation. As I discuss here, recent studies have begun to reveal how their unique circular topology evolved. Cyclization is achieved by hijacking existing plant proteolytic enzymes and operating them in ‘reverse’ to form a peptide bond between the N- and C-termini of a linear precursor. Such studies suggest that circular proteins are more common in the plant kingdom than was previously thought, and their exceptional stability has led to their application as protein-engineering templates in drug design.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 43 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 05 Feb 2010, 11:05:51 EST by Susan Allen on behalf of Institute for Molecular Bioscience