Lipidic Systems for In Vivo siRNA Delivery

Wu, SY and McMillan, NAJ (2009) Lipidic Systems for In Vivo siRNA Delivery. AAPS JOURNAL, 11 4: 639-652. doi:10.1208/s12248-009-9140-1


Author Wu, SY
McMillan, NAJ
Title Lipidic Systems for In Vivo siRNA Delivery
Formatted title
Lipidic Systems for In Vivo siRNA Delivery
Journal name AAPS JOURNAL   Check publisher's open access policy
ISSN 1550-7416
Publication date 2009-12
Sub-type Article (original research)
DOI 10.1208/s12248-009-9140-1
Volume 11
Issue 4
Start page 639
End page 652
Total pages 14
Editor Fung, H
Place of publication United States
Publisher Springer New York LLC
Collection year 2010
Language eng
Subject C1
111504 Pharmaceutical Sciences
920102 Cancer and Related Disorders
Abstract The ability of small-interfering RNA (siRNA) to silence specific target genes not only offers a tool to study gene function but also represents a novel approach for the treatment of various human diseases. Its clinical use, however, has been severely hampered by the lack of delivery of these molecules to target cell populations in vivo due to their instability, inefficient cell entry, and poor pharmacokinetic profile. Various delivery vectors including liposomes, polymers, and nanoparticles have thus been developed in order to circumvent these problems. This review presents a comprehensive overview of the barriers and recent progress for both local and systemic delivery of therapeutic siRNA using lipidic vectors. Different strategies for formulating these siRNA-loaded lipid particles as well as the general concern about their safe use in vivo will also be discussed. Finally, current advances in the targeted delivery of siRNA and their impacts on the field of RNA interference (RNAi)-based therapy will be presented.
Keyword in vivo delivery
liposomes
siRNA
SMALL INTERFERING RNA
CFTR GENE-TRANSFER
ACUTE LUNG INJURY
TARGETED DELIVERY
CYSTIC-FIBROSIS
LIPOSOME COMPLEXES
CATIONIC LIPOSOME
NASAL EPITHELIUM
PANCREATIC ADENOCARCINOMA
COLORECTAL-CARCINOMA
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Pharmacy Publications
UQ Diamantina Institute Publications
 
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Created: Sun, 31 Jan 2010, 00:07:40 EST