The impact of changes in hormone therapy on breast cancer incidence in the US population

Coombs, NJ, Cronin, KA, Taylor, RJ, Freedman, AN and Boyages, J (2010) The impact of changes in hormone therapy on breast cancer incidence in the US population. Cancer Causes and Control, 21 1: 83-90. doi:10.1007/s10552-009-9437-5

Author Coombs, NJ
Cronin, KA
Taylor, RJ
Freedman, AN
Boyages, J
Title The impact of changes in hormone therapy on breast cancer incidence in the US population
Journal name Cancer Causes and Control   Check publisher's open access policy
ISSN 0957-5243
Publication date 2010-01
Year available 2009
Sub-type Article (original research)
DOI 10.1007/s10552-009-9437-5
Volume 21
Issue 1
Start page 83
End page 90
Total pages 8
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Collection year 2011
Language eng
Formatted abstract
Objective: This study combines population changes in hormone therapy (HT) use with reported relative risks to estimate directly the impact of reductions in HT use on US breast cancer incidence.

Using breast cancer incidence rates and prevalence estimates of HT use, the breast cancer incidence in HT users and non-users was derived. Attributable fraction calculations used risk data from the Million Women Survey (MWS), Collins' meta-analysis (CMA), and the initial or later data from the Women's Health Initiative (WHI) study.

Between 2000 and 2005, HT use fell from 25.0 to 11.3%. The reported breast cancer incidence (in women aged 40-79) fell 8.8%. Derived incidence rates among non-users of HT remained unchanged (MWS or later WHI data) or slightly lower (initial WHI and CMA data), suggesting reductions in incidence are almost entirely (MWS or later WHI data) or partially (initial WHI or CMA data) due to reduced HT use.

Changes in reported breast cancer incidence may be partially or largely explained by changes in HT use in the US population. © 2009 Springer Science+Business Media B.V.
Keyword Breast neoplasms
Hormone replacement therapy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 1 October 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Sun, 31 Jan 2010, 00:04:46 EST