Ephrin expression and function in cancer

McCarron, JK, Stringer, BW, Day, BW and Boyd, AW (2010) Ephrin expression and function in cancer. Future Oncology, 6 1: 165-176. doi:10.2217/FON.09.146

Author McCarron, JK
Stringer, BW
Day, BW
Boyd, AW
Title Ephrin expression and function in cancer
Journal name Future Oncology   Check publisher's open access policy
ISSN 1479-6694
Publication date 2010-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2217/FON.09.146
Open Access Status
Volume 6
Issue 1
Start page 165
End page 176
Total pages 12
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2011
Language eng
Abstract Ephrins are cell membrane-associated signaling proteins bound by transmembrane Eph receptors on juxtaposed cells. Eph-ephrin interactions result in bidirectional signaling within both receptor- and ligand-bearing cells, with diverse consequences for cell morphology and behavior. Such interactions are especially important during early vertebrate development, and growing evidence has revealed equally important roles in adult-tissue homeostasis. As for the Eph receptors, abnormal expression of ephrins is associated with disease, especially cancer. The ephrins have received less attention than the Ephs in the literature, owing, in part, to their later discovery and that they are fewer in number. Here, we attempt to redress this imbalance and provide an 'ephrin-centric' discussion of the expression and function of ephrins in cancer. © 2010 Future Medicine Ltd.
Keyword Cancer
Eph receptor
Patient survival
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Queensland Brain Institute Publications
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Sun, 31 Jan 2010, 00:03:53 EST