Antiepileptic drugs in Australia: 2002-2007

Hollingworth, Samantha A. and Eadie, Mervyn J. (2010) Antiepileptic drugs in Australia: 2002-2007. Pharmacoepidemiology and Drug Safety, 19 1: 82-89. doi:10.1002/pds.1871


Author Hollingworth, Samantha A.
Eadie, Mervyn J.
Title Antiepileptic drugs in Australia: 2002-2007
Journal name Pharmacoepidemiology and Drug Safety   Check publisher's open access policy
ISSN 1099-1557
1053-8569
Publication date 2010-01
Year available 2009
Sub-type Article (original research)
DOI 10.1002/pds.1871
Volume 19
Issue 1
Start page 82
End page 89
Total pages 8
Place of publication Chichester, West Sussex
Publisher Wiley
Collection year 2011
Language eng
Subject 1117 Public Health and Health Services
Formatted abstract
Purpose
With the marketing of a number of new antiepileptic drugs (AEDs) in recent years it seemed possible that the pattern of Australian prescribing for patients with epilepsy may have been changing. We examined the trends in the prescribing of subsidised AEDs in the Australian population from 2002 to 2007.

Methods
We analysed the Medicare Australia and Drug Utilisation Sub-Committee databases for script data for AEDs from 2002 to 2007 in 5-year age groups by gender and by class of prescriber. Scripts were converted to defined daily doses (DDDs)/1000/day using Australian Bureau of Statistics population data.

Results

Overall AED use (mainly valproate, lamotrigine and levetiracetam) increased progressively in 2002-2007 from 9.33 to 10.12 DDD/1000 population/day. Sodium valproate was the most widely used agent followed by carbamazepine then phenytoin. Amount of AED used increased in those aged in their 20s and 30s to plateau between 40 and 90 years. Use peaked in those aged 80-84 years and was slightly higher in males than females.

Conclusions
The rate of increase in the prescribing of AEDs remained steady between 2002 and 2007. The gender differences in prescribing reflect the higher prevalence of epilepsy in men and higher individual dosages used when many AEDs are prescribed on a body weight basis. The high use of some of these drugs in elderly people (80 years) warrants further exploration. There is growing use of lamotrigine and gabapentin for indications apart from epilepsy - most likely neuropathic pain and mood disorders. Copyright © 2009 John Wiley & Sons, Ltd. 
Keyword Antiepileptic drugs
Utilisation
Prescribing
Epilepsy
Trials
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 2 Oct 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2011 Collection
School of Public Health Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 28 times in Scopus Article | Citations
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Created: Sun, 31 Jan 2010, 00:01:51 EST