sRAGE, S100 proteins and PTPN22 C1858T genetic polymorphism in rheumatoid arthritis

Yueh-Sheng Chen (2009). sRAGE, S100 proteins and PTPN22 C1858T genetic polymorphism in rheumatoid arthritis MPhil Thesis, Diamantina Institute of Cancer, Immunology and Metabolic Medicine, The University of Queensland.

       
Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
s41086502_MPhil_resubmission_final.pdf s41086502_MPhil_Final Resubmission application/pdf 1.43MB 14
Author Yueh-Sheng Chen
Thesis Title sRAGE, S100 proteins and PTPN22 C1858T genetic polymorphism in rheumatoid arthritis
School, Centre or Institute Diamantina Institute of Cancer, Immunology and Metabolic Medicine
Institution The University of Queensland
Publication date 2009-02
Thesis type MPhil Thesis
Supervisor Ranjeny Thomas
Matthew A. Brown
Total pages 166
Total colour pages 6
Total black and white pages 160
Subjects 11 Medical and Health Sciences
Abstract/Summary Rheumatoid arthritis is a chronic inflammatory autoimmune disease. Measurement of the level of serum markers (sRAGE, S100A9, S100A8 and S100A12) and genetic testing for the presence of the PTPN22 genetic polymorphism could help elucidate the underlying cause of inflammation and complications in RA, such as atherosclerosis. Therefore, serum levels of sRAGE, S100A9, S100A8 and S100A12 were measured by ELISA in patients with established RA (n=138). The associations between the serum levels of these molecules; and inflammatory markers and RA complications were analysed by multiple linear regression modelling. Established RA patients (n=192) were investigated for the PTPN22 C1858T genetic polymorphism by PCR-RFLP. Multiple logistic regression modelling was used to examine the association between PTPN22 C1858T genetic polymorphism and inflammatory markers and RA complications. In RA patients, we found that serum levels of S100A9 were associated with the body mass index (BMI); and the presence of S100A8 and S100A12. The serum levels of S100A8 in RA patients were associated with the presence of anti-citrullinated peptide antibodies, rheumatoid factor and S100A9. The serum levels of S100A12 in RA patients were associated with the presence of anti-citrullinated peptide antibodies and S100A9; and a history of diabetes. Inflammatory markers and RA complications were not associated with the PTPN22 genetic polymorphism in established RA patients; serum level of triglyceride was the only variable associated with PTPN22 C1858T in multiple logistic regression analysis. Taken together, these data suggest that serum levels of sRAGE, S100A9 and S100A12 protein may be useful correlates of inflammation and autoantibody production in RA patients. Further studies are recommended to determine whether these markers predict clinical outcomes when measured at the onset of RA.
Keyword Rheumatoid Arthritis (ra)
RAGE
sRAGE
S100A9
S100A8
S100A12
Cardiovascular diseases
Vascular Complications
PTPN22
Regression Analysis
Additional Notes Printed in colour p24, p52, p74, p100, p15-159 (PDF file page number)

 
Citation counts: Google Scholar Search Google Scholar
Created: Thu, 28 Jan 2010, 17:26:04 EST by Mr Yueh Chen on behalf of Library - Information Access Service