Variation in antifungal prophylaxis strategies in lung transplantation

Husain, S., Zaldonis, D., Kusne, S., Kwak, E.J., Paterson, David L. and McCurry, K.R. (2006) Variation in antifungal prophylaxis strategies in lung transplantation. Transplant Infectious Disease, 8 4: 213-218. doi:10.1111/j.1399-3062.2006.00156.x


Author Husain, S.
Zaldonis, D.
Kusne, S.
Kwak, E.J.
Paterson, David L.
McCurry, K.R.
Title Variation in antifungal prophylaxis strategies in lung transplantation
Journal name Transplant Infectious Disease   Check publisher's open access policy
ISSN 1399-6975
1398-2273
1399-3062
Publication date 2006-12
Sub-type Article (original research)
DOI 10.1111/j.1399-3062.2006.00156.x
Volume 8
Issue 4
Start page 213
End page 218
Total pages 6
Place of publication Copenhagen, Denmark
Publisher Munksgaard International
Language eng
Subject 110708 Transplantation Immunology
1115 Pharmacology and Pharmaceutical Sciences
1117 Public Health and Health Services
Abstract We conducted a survey of 50 lung transplant centers across the world to evaluate the variation in antifungal prophylaxis practices. These 50 centers performed 63% of the world's lung transplants reported in 2001. Eighty-six percent (43/50) of the centers responded to the survey. Sixty-nine percent (30/43) of centers used universal antifungal prophylaxis. Aerosolized amphotericin B deoxycholate (AmBd) alone or in combination with itraconazole was used at 56% (24/43) of centers. The median duration of prophylaxis with aerosolized AmBd and itraconazole was 30 and 90 days, respectively. Seventy-four percent of the centers surveyed agreed to participate in future research prophylaxis protocols, which they felt should include both diagnostic and therapeutic arms. Our survey is the first documentation of the international variation in antifungal prophylactic strategies in lung transplant recipients, and underscores the need for multicenter, randomized trials of antifungal prophylaxis in lung transplant recipients.
Keyword Fungus
Prophylaxis
Lung transplant
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Centre for Clinical Research Publications
 
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Created: Wed, 27 Jan 2010, 15:02:50 EST by Macushla Boyle on behalf of Royal Brisbane Clinical School