Genetic studies in osteoporosis - the end of the beginning

Duncan, Emma L. and Brown, Matthew A. (2008) Genetic studies in osteoporosis - the end of the beginning. Arthritis Research and Therapy, 10 5: 214.1-214.8. doi:10.1186/ar2479

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Author Duncan, Emma L.
Brown, Matthew A.
Title Genetic studies in osteoporosis - the end of the beginning
Journal name Arthritis Research and Therapy   Check publisher's open access policy
ISSN 1465-9905
Publication date 2008-09-12
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/ar2479
Open Access Status File (Publisher version)
Volume 10
Issue 5
Start page 214.1
End page 214.8
Total pages 8
Editor Peter E. Lipsky
Ravinder N. Maini
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Abstract Osteoporosis and disorders of bone fragility are highly heritable, but despite much effort the identities of few of the genes involved has been established. Recent developments in genetics such as genome-wide association studies are revolutionizing research in this field, and it is likely that further contributions will be made through application of next-generation sequencing technologies, analysis of copy number variation polymorphisms, and high-throughput mouse mutagenesis programs. This article outlines what we know about osteoporosis genetics to date and the probable future directions of research in this field.
Keyword Bone mineral density (BMD)
Copy number variation(CNV)
Lipoprotein-related receptor protein (LRP5)
Single nucleotide polymorphism (SNP)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
Cancer Prevention Research Centre Publications
UQ Diamantina Institute - Open Access Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Wed, 27 Jan 2010, 09:49:29 EST by Rosalind Blair on behalf of UQ Diamantina Institute