Effect of a selective decontamination of the digestive tract regimen including parenteral Cefepime on establishment of intestinal colonization with Vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in mice

Paterson, David L., Stiefel, Usha and Donskey, Curtis J. (2006) Effect of a selective decontamination of the digestive tract regimen including parenteral Cefepime on establishment of intestinal colonization with Vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in mice. Antimicrobial Agents and Chemotherapy, 50 7: 2537-2540. doi:10.1128/AAC.00071-06

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Author Paterson, David L.
Stiefel, Usha
Donskey, Curtis J.
Title Effect of a selective decontamination of the digestive tract regimen including parenteral Cefepime on establishment of intestinal colonization with Vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in mice
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
Publication date 2006-07
Year available 2006
Sub-type Article (original research)
DOI 10.1128/AAC.00071-06
Open Access Status File (Publisher version)
Volume 50
Issue 7
Start page 2537
End page 2540
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Subject 110309 Infectious Diseases
1108 Medical Microbiology
1115 Pharmacology and Pharmaceutical Sciences
1103 Clinical Sciences
Abstract In mice, a selective decontamination of the digestive tract regimen consisting of orogastric tobramycin, polymyxin E, and amphotericin B in combination with subcutaneous cefepime inhibited gram-negative bacilli, including Klebsiella pneumoniae, and did not promote vancomycin-resistant Enterococcus spp. (VRE) colonization. However, concurrent administration of subcutaneous ampicillin-sulbactam resulted in promotion of VRE.
Keyword Decontamination
Parenteral Cefepime
Orogastric tobramycin
Polymyxin E
Amphotericin B
Cefepime
Bacilli
Klebsiella pneumoniae
Vancomycin
Enterococcus
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Centre for Clinical Research Publications
 
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Created: Mon, 25 Jan 2010, 14:42:45 EST by Macushla Boyle on behalf of Royal Brisbane Clinical School