Postnatal maturational changes in rat pelvic autonomic ganglion cells: A mixture of steroid-dependent and -independent effects

Kanjhan, R., Osborne, P. B., Ouyang, M. and Keast, J. R. (2003) Postnatal maturational changes in rat pelvic autonomic ganglion cells: A mixture of steroid-dependent and -independent effects. Journal of Neurophysiology, 89 1: 315-323. doi:10.1152/jn.00479.2002

Author Kanjhan, R.
Osborne, P. B.
Ouyang, M.
Keast, J. R.
Title Postnatal maturational changes in rat pelvic autonomic ganglion cells: A mixture of steroid-dependent and -independent effects
Journal name Journal of Neurophysiology   Check publisher's open access policy
ISSN 0022-3077
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1152/jn.00479.2002
Volume 89
Issue 1
Start page 315
End page 323
Total pages 9
Place of publication Bethesda, MD, U.S.A.
Publisher American Physiological Society
Language eng
Subject 1109 Neurosciences
1116 Medical Physiology
Formatted abstract
Androgens have potent effects on the maturation and maintenance of a number of neural pathways involved in reproductive behaviors in males. Most studies in this area have focused on central pathways, but androgen receptors are expressed by many peripheral neurons innervating reproductive organs, and previous studies have demonstrated structural and chemical changes in these neurons at puberty and after castration. We have performed the first electrophysiological comparison of pelvic autonomic ganglion neurons in male rats before and after puberty and following pre- or postpubertal castration. Studies were performed in vitro on intact ganglia with hypogastric and pelvic nerves attached to allow synaptic activation of sympathetic or parasympathetic neurons, respectively. Pelvic ganglion neurons underwent many changes in their passive and active membrane properties over the pubertal period, and some of these changes were dependent on exposure to circulating androgens. The most pronounced steroid-dependent effects were on membrane capacitance (soma size) in sympathetic neurons and duration of the action potential afterhyperpolarization in tonic neurons. Our study also showed that rat pelvic ganglion cells and their synaptic inputs were more diverse than previously reported. In conclusion, this study demonstrated that rat pelvic ganglion neurons undergo considerable postnatal changes in their electrophysiological properties. The steroid dependence of some of these changes indicates that circulating androgens may influence reproductive behaviors at many locations within the nervous system not just in the brain and spinal cord.
Copyright © 2003 The American Physiological Society
Keyword Guinea pig
Sympathetic neurons
Immunohistochemical characterization
Electrical properties
Hypogastric ganglion
Celiac ganglion
Nervous system
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Queensland Brain Institute Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 19 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 25 Jan 2010, 14:35:53 EST by Jon Swabey on behalf of Queensland Brain Institute