Infections with nontyphoidal Salmonella species roducing TEM-63 or a novel TEM enzyme, TEM-131, in South Africa

Kruger, Tersia, Szabo, Dora, Keddy, Karen H., Deeley, Kathleen, Marsh, Jane W., Hujer, Andrea M., Bonomo, Robert A. and Paterson, David L. (2004) Infections with nontyphoidal Salmonella species roducing TEM-63 or a novel TEM enzyme, TEM-131, in South Africa. Antimicrobial Agents and Chemotherapy, 48 11: 4263-4270. doi:10.1128/AAC.48.11.4263-4270.2004

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Author Kruger, Tersia
Szabo, Dora
Keddy, Karen H.
Deeley, Kathleen
Marsh, Jane W.
Hujer, Andrea M.
Bonomo, Robert A.
Paterson, David L.
Title Infections with nontyphoidal Salmonella species roducing TEM-63 or a novel TEM enzyme, TEM-131, in South Africa
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 1098-6596
0066-4804
Publication date 2004-11
Year available 2004
Sub-type Article (original research)
DOI 10.1128/AAC.48.11.4263-4270.2004
Open Access Status File (Publisher version)
Volume 48
Issue 11
Start page 4263
End page 4270
Total pages 8
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Subject 1103 Clinical Sciences
110309 Infectious Diseases
1108 Medical Microbiology
110801 Medical Bacteriology
Abstract Salmonella spp. producing extended-spectrum beta-lactamases (ESBLs) have been reported in many countries, but there is no information on their prevalence in Africa. ESBL-producing Salmonella enterica serotype Isangi and S. enterica serotype Typhimurium strains have been noted in South Africa since 2001. A total of 160 consecutive isolates of Salmonella spp. were collected from 13 hospitals located in different cities in South Africa over a 5-month period from December 2002 to April 2003. All strains were screened for production of ESBLs by the double disk diffusion test and for AmpC production by assessing resistance to cefoxitin. blaSHV, blaTEM, blaCTX-M, and blaCMY-2 were sought from all ESBL-positive and cefoxitin-resistant isolates. A total of 15.6% (25 of 160) isolates produced SHV or TEM ESBLs, and 1.9% (3 of 160) produced CMY-2. Nine S. enterica serotype Typhimurium, eight S. enterica serotype Isangi, and three S. enterica serotype Muenchen strains produced either TEM-63 or a derivative of TEM-63 designated TEM-131. Both TEM-63 and TEM-131 have an isoelectric point of 5.6, and their sequences have the following amino acid substitutions compared to the TEM-1 sequence: Leu21Phe, Glu104Lys, Arg164Ser, and Met182Thr. Additionally, TEM-131 has an Ala237Thr substitution. ESBL-producing Salmonella spp. have become a significant public health problem in South Africa with particular implications for the treatment of serious nontyphoidal Salmonella infections in children, for whom extended-spectrum cephalosporins were the preferred treatment.
Keyword Salmonella spp.
beta-lactamases
ESBLs
Nontyphoidal
Salmonella
TEM
South Africa
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Centre for Clinical Research Publications
 
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Created: Mon, 25 Jan 2010, 11:22:27 EST by Macushla Boyle on behalf of Royal Brisbane Clinical School