Progress in spondylarthritis: progress in studies of the genetics of ankylosing spondylitis

Brown, Matthew A. (2009) Progress in spondylarthritis: progress in studies of the genetics of ankylosing spondylitis. Arthritis Research and Therapy, 11 5: 254.1-254.6. doi:10.1186/ar2692

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Author Brown, Matthew A.
Title Progress in spondylarthritis: progress in studies of the genetics of ankylosing spondylitis
Journal name Arthritis Research and Therapy   Check publisher's open access policy
ISSN 1465-9905
1478-6354
1478-6362
Publication date 2009-10-29
Year available 2009
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/ar2692
Open Access Status File (Publisher version)
Volume 11
Issue 5
Start page 254.1
End page 254.6
Total pages 6
Editor P. E. Lipsky
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2010
Language eng
Abstract The advent of high-throughput SNP genotyping methods has advanced research into the genetics of common complex genetic diseases such as ankylosing spondylitis (AS) rapidly in recent times. The identification of associations with the genes IL23R and ERAP1 have been robustly replicated, and advances have been made in studies of the major histocompatibility complex genetics of AS, and of KIR gene variants and the disease. The findings are already being translated into increased understanding of the immunological pathways involved in AS, and raising novel potential therapies. The current studies in AS remain underpowered, and no full genomewide association study has yet been reported in AS; such studies are likely to add to the significant advances that have already been made.
Keyword Crohns-disease
HLA-B27 Polymorphism
Susceptibility Locus
Association
Population
Variants
Subtypes
IL23R
HLA-B-Asterisk-1403
Psoriasis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: ERA 2012 Admin Only
UQ Diamantina Institute - Open Access Collection
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Sun, 24 Jan 2010, 10:05:48 EST