Synthesis and characterization of dual radiolabeled layered double hydroxide nanoparticles for use in in vitro and in vivo nanotoxicology studies

Musumeci, Anthony W., Schiller, Tara L., Xu, Zhi Ping, Minchin, Rodney F., Martin, Darren J. and Smith, Suzanne V. (2010) Synthesis and characterization of dual radiolabeled layered double hydroxide nanoparticles for use in in vitro and in vivo nanotoxicology studies. The Journal of Physical Chemistry Part C: Nanomaterials and Interfaces, 114 2: 734-740. doi:10.1021/jp905347x


Author Musumeci, Anthony W.
Schiller, Tara L.
Xu, Zhi Ping
Minchin, Rodney F.
Martin, Darren J.
Smith, Suzanne V.
Title Synthesis and characterization of dual radiolabeled layered double hydroxide nanoparticles for use in in vitro and in vivo nanotoxicology studies
Journal name The Journal of Physical Chemistry Part C: Nanomaterials and Interfaces   Check publisher's open access policy
ISSN 1932-7447
1932-7455
Publication date 2010-01-21
Year available 2009
Sub-type Article (original research)
DOI 10.1021/jp905347x
Volume 114
Issue 2
Start page 734
End page 740
Total pages 7
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2010
Language eng
Formatted abstract
Layered double hydroxide (LDH) nanomaterials are currently the focus of intense scientific interest due to their potential application in drug and gene delivery research. However, the emerging field of nanotoxicology requires the development of new and more sensitive methodologies to follow the in vivo delivery kinetics as well as the persistence and bioaccumulation of the LDH carriers subsequent to delivery of the payload to the target area. Radioisotopic labeling offers very high detection sensitivity (<10-14 moles) and straightforward quantitation with respect to other labeling techniques. We have shown that incorporation of naturally occurring Co2+ and Ga 3+ cations into the LDH structure has a negligible effect on the physiochemical properties of the pristine nanoparticles. Radiolabeling through dual isomorphous substitution of 57Co2+ and 67Ga3+ into the LDH structure offers the utility to accurately track and also follow the structural dissolution of these nanomaterials over a range of biologically relevant pHs. Radiolabeled-LDH kinetic release profiles in conjunction with transmission electron microscopy and X-ray diffraction studies have revealed that the bulk dissolution of LDH occurs with no preferential leaching of the 57Co2+ or 67Ga3+ metal species from the crystal structure. Furthermore, the present study clearly demonstrates how radiolabeling methodologies described here may be adapted for use in other similar clay systems and allow for the first time noninvasive imaging and monitoring of the fate of nanoparticles.
© 2010 American Chemical Society.
Keyword Delivery
Al
Hydrotalcite
Nanohybrids
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Publication Date (Web): December 23, 2009.

 
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Created: Sun, 24 Jan 2010, 10:03:43 EST