Meropenem administered as a prolonged infusion to treat serious gram-negative central nervous system infections

Capitano, Blair, Nicolau, David P., Potoski, Brian A., Byers, Karin E., Horowitz, Michael, Venkataramanan, Raman and Paterson, David L. (2004) Meropenem administered as a prolonged infusion to treat serious gram-negative central nervous system infections. Pharmacotherapy, 24 6: 803-807. doi:10.1592/phco.24.8.803.36070


Author Capitano, Blair
Nicolau, David P.
Potoski, Brian A.
Byers, Karin E.
Horowitz, Michael
Venkataramanan, Raman
Paterson, David L.
Title Meropenem administered as a prolonged infusion to treat serious gram-negative central nervous system infections
Journal name Pharmacotherapy   Check publisher's open access policy
ISSN 0277-0008
Publication date 2004-06
Year available 2004
Sub-type Article (original research)
DOI 10.1592/phco.24.8.803.36070
Volume 24
Issue 6
Start page 803
End page 807
Total pages 5
Place of publication Boston, Ma. U.S.A.
Publisher Pharmacotherapy Publishing
Language eng
Subject 110903 Central Nervous System
1115 Pharmacology and Pharmaceutical Sciences
110309 Infectious Diseases
Abstract The treatment of gram-negative infection of the central nervous system (CNS) presents a clinical challenge due to antibiotic resistance and difficulties with penetration into the cerebrospinal fluid (CSF). Two patients with gram-negative CNS infections were treated successfully with high-dose, prolonged infusions of meropenem. The CSF meropenem concentrations exceeded the minimum inhibitory concentration of the pathogen for virtually the entire dosing interval in both cases. Our experience demonstrates that dosage modification to maximize pharmacodynamic targets and bactericidal activity may be practically applied to optimize antibiotic treatment for difficult-totreat CNS infections.
Keyword Meropenem
Central nervous system
Gram-negative central nervous system infection
Antibiotic resistance
Antibiotic management,
Pharmacodynamics
Pharmacokinetics
Meningitis
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Centre for Clinical Research Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 20 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 22 Jan 2010, 11:41:18 EST by Macushla Boyle on behalf of Royal Brisbane Clinical School