Decanalization and the origin of complex disease

Gibson, G.C. (2009) Decanalization and the origin of complex disease. Nature Reviews. Genetics, 10 2: 134-140. doi:10.1038/nrg2502

Author Gibson, G.C.
Title Decanalization and the origin of complex disease
Journal name Nature Reviews. Genetics   Check publisher's open access policy
ISSN 1471-0056
Publication date 2009-02
Year available 2009
Sub-type Article (original research)
DOI 10.1038/nrg2502
Volume 10
Issue 2
Start page 134
End page 140
Total pages 7
Editor Flintolf, L.
Place of publication United Kingdom
Publisher Nature Publishing Group
Collection year 2010
Language eng
Subject C1
0604 Genetics
970106 Expanding Knowledge in the Biological Sciences
Abstract Complex genetic disease is caused by the interaction between genetic and environmental variables and is the predominant cause of mortality globally. Recognition that susceptibility arises through the combination of multiple genetic pathways that influence liability factors in a nonlinear manner suggests that a process of 'decanalization' contributes to the epidemic nature of common genetic diseases. The rapid evolution of the human genome combined with marked environmental and cultural perturbation in the past two generations might lead to the uncovering of cryptic genetic variation that is a major source of disease susceptibility.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Biological Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 105 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 125 times in Scopus Article | Citations
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Created: Thu, 21 Jan 2010, 15:48:27 EST by Hayley Ware on behalf of School of Biological Sciences