Promoting central nervous system regeneration: Lessons from cranial nerve I

Ruitenberg, Marc J. and Vukovic, Jana (2008) Promoting central nervous system regeneration: Lessons from cranial nerve I. Restorative Neurology and Neuroscience, 26 2-3: 183-196.

Author Ruitenberg, Marc J.
Vukovic, Jana
Title Promoting central nervous system regeneration: Lessons from cranial nerve I
Journal name Restorative Neurology and Neuroscience   Check publisher's open access policy
ISSN 0922-6028
Publication date 2008
Sub-type Article (original research)
Volume 26
Issue 2-3
Start page 183
End page 196
Total pages 14
Editor P. N. Anderson
Place of publication Amsterdam, The Netherlands
Publisher IOS Press
Language eng
Abstract The olfactory nerve differs from cranial nerves III-XII in that it contains a specialised type of glial cell, called 'olfactory ensheathing cell' (OEC), rather than Schwann cells. In addition, functional neurogenesis persists postnatally in the olfactory system, i.e. the primary olfactory pathway continuously rebuilds itself throughout adult life. The presence of OECs in the olfactory nerve is thought to be critical to this continuous growth process. Because of this intrinsic capacity for self-repair, the mammalian olfactory system has proved as a useful model in neuroregeneration studies. In addition, OECs have been used in transplantation studies to promote pathway regeneration elsewhere in the nervous system. Here, we have reviewed the parameters that allow for repair within the primary olfactory pathway and the role that OECs are thought to play in this process. We conclude that, in addition to intrinsic growth potential, the presence of an aligned substrate to the target structure is a fundamental prerequisite for appropriate restoration of connectivity with the olfactory bulb. Hence, strategies to promote regrowth of injured nerve pathways should incorporate usage of aligned, oriented substrates of OECs or other cellular conduits with additional intervention to boost neuronal cell body responses to injury and/or neutralisation of putative inhibitors.
Keyword Central nervous system
Olfactory nerve
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Issue Title: Axonal Regeneraton and Repair of the central Nervous System

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
School of Biomedical Sciences Publications
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Created: Thu, 21 Jan 2010, 12:21:48 EST by Macushla Boyle on behalf of Faculty of Science