Pseudomonas aeruginosa transmission is infrequent in New Zealand cystic fibrosis clinics

Schmid, J., Ling, L. J., Leung, J. L. S., Zhang, N., Kolbe, J., Wesley, A. W., Mills, G. D., Brown, P. J., Jones, D. T., Laing, R. T. R., Pattemore, P. K., Taylor, D. R. and Grimwood, K. (2008) Pseudomonas aeruginosa transmission is infrequent in New Zealand cystic fibrosis clinics. European Respiratory Journal, 32 6: 1583-1590. doi:10.1183/09031936.00099508


Author Schmid, J.
Ling, L. J.
Leung, J. L. S.
Zhang, N.
Kolbe, J.
Wesley, A. W.
Mills, G. D.
Brown, P. J.
Jones, D. T.
Laing, R. T. R.
Pattemore, P. K.
Taylor, D. R.
Grimwood, K.
Title Pseudomonas aeruginosa transmission is infrequent in New Zealand cystic fibrosis clinics
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
Publication date 2008-12
Year available 2008
Sub-type Article (original research)
DOI 10.1183/09031936.00099508
Volume 32
Issue 6
Start page 1583
End page 1590
Total pages 8
Place of publication Cobenhagen, Denmark
Publisher European Respiratory Society
Language eng
Subject 1103 Clinical Sciences
1101 Medical Biochemistry and Metabolomics
110105 Medical Biochemistry: Nucleic Acids
Abstract Pseudomonas aeruginosa is an important pathogen in cystic fibrosis (CF). Although most patients harbour unique P. aeruginosa isolates, some clinics report patients sharing common strains. The overall importance of person-to-person transmission in P. aeruginosa acquisition and whether routine patient segregation is necessary remains uncertain. The present authors therefore investigated the extent of P. aeruginosa transmission in New Zealand CF clinics. New Zealand’s seven major CF centres were assessed, combining epidemiological data with computer-assisted SalI DNA fingerprinting of 496 isolates from 102 patients. One cluster of related isolates was significantly more prevalent in the largest clinic than expected by chance. The seven patients with isolates belonging to this cluster had more contact with each other than the remaining patients attending this centre. No other convincing evidence of transmission was found in any of the other smaller clinics. Three P. aeruginosa strains believed to be transmissible between patients in Australian and British CF clinics are present in New Zealand, but there was no definite evidence they had spread. Pseudomonas aeruginosa transmission is currently infrequent in New Zealand cystic fibrosis clinics. This situation could change rapidly and ongoing surveillance is required. The current results confirm that computer-assisted SalI DNA fingerprinting is ideally suited for such surveillance.
Keyword Cystic fibrosis
DNA typing
Pseudomonas aeruginosa
Transmission
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 20 Jan 2010, 15:04:33 EST by Macushla Boyle on behalf of Royal Brisbane Clinical School