An echovirus type 33 winter outbreak in New Zealand

Huang, Q. Sue, Carr, Julia M., Nix, W. Allan, Oberste, M. Steven, Kilpatrick, David R., Pallansch, Mark A., Croxson, Margaret. C., Lindeman, Jennifer A., Baker, Michael G. and Grimwood, Keith (2003) An echovirus type 33 winter outbreak in New Zealand. Clinical Infectious Diseases, 37 5: 650-657. doi:10.1086/376915


Author Huang, Q. Sue
Carr, Julia M.
Nix, W. Allan
Oberste, M. Steven
Kilpatrick, David R.
Pallansch, Mark A.
Croxson, Margaret. C.
Lindeman, Jennifer A.
Baker, Michael G.
Grimwood, Keith
Title An echovirus type 33 winter outbreak in New Zealand
Journal name Clinical Infectious Diseases   Check publisher's open access policy
ISSN 1058-4838
1537-6591
Publication date 2003-09-01
Sub-type Article (original research)
DOI 10.1086/376915
Volume 37
Issue 5
Start page 650
End page 657
Total pages 8
Place of publication Chicago, U.S.A.
Publisher University of Chicago Press
Language eng
Subject 1103 Clinical Sciences
Abstract Echovirus type 33 (E33) is a relatively uncommon enterovirus. An E33 outbreak during the winter of 2000 in New Zealand led to 75 virologically‐confirmed cases of E33 infection (2.6 cases per 100,000 individuals). Sixty‐six (88%) of the 75 patients were aged <30 years, with the highest rates of infection recorded in Maori and Pacific ethnic groups. Overall, 47 (84%) of 56 patients whose cases were analyzed had either aseptic meningitis or encephalitis. Central nervous system involvement was more common after infancy (43 of 45 non‐infant patients vs. 4 of 11 infants [relative risk, 2.6; 95% CI, 1.5–4.3]). Two infants died, including a neonate with fulminant hepatitis. Independent of symptom duration, neutrophil‐predominant pleocytosis was detected in 17 (41%) of 41 cerebrospinal fluid specimens. Virus isolates could not be definitively typed by antibody neutralization testing but were identified as E33 by partial sequencing of the VP‐1 capsid gene. The isolates were closely related to strains from Australia and Oman. Molecular typing, together with a serotype‐specific E33 PCR, improved the speed and effectiveness of the outbreak investigation. © 2003 by the Infectious Diseases Society of America
Keyword Echovirus type 33 (E33)
New Zealand
Enterovirus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Presented in part: Annual Scientific Meeting of the New Zealand Microbiology Society, Wellington, New Zealand, 18–21 November 2001.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 20 Jan 2010, 09:52:33 EST by Gerald Martin on behalf of Faculty Of Health Sciences