Vitamin B status and cognitive performance in preclinical and clinical Alzheimer's disease: Data from the Kungsholmen Project

Wahlin, Åke, Fahlander, Kjell, Robins Wahlin, Tarja - Brita, Bunce, David and Bäckman, Lars (2007) Vitamin B status and cognitive performance in preclinical and clinical Alzheimer's disease: Data from the Kungsholmen Project. Dementia and Geriatric Cognitive Disorders, 25 1: 23-31. doi:10.1159/000111129


Author Wahlin, Åke
Fahlander, Kjell
Robins Wahlin, Tarja - Brita
Bunce, David
Bäckman, Lars
Title Vitamin B status and cognitive performance in preclinical and clinical Alzheimer's disease: Data from the Kungsholmen Project
Journal name Dementia and Geriatric Cognitive Disorders   Check publisher's open access policy
ISSN 1420-8008
1421-9824
Publication date 2007
Year available 2007
Sub-type Article (original research)
DOI 10.1159/000111129
Volume 25
Issue 1
Start page 23
End page 31
Total pages 9
Place of publication Basel, Switzerland
Publisher Karger
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
Background/Aims: 
The impact of vitamin B status on cognitive functioning in Alzheimer's disease (AD) is disputed. Using a population-based sample, we examined the associations of vitamin B12 and folate with cognitive functioning in clinical (n = 44) and preclinical (n = 39) AD.

Methods: 
The groups were subdivided in terms of low (<200 pmol/l) versus normal levels of B12 and low (<13 nmol/l) versus normal folate levels. Participants were administered tests of verbal and nonverbal episodic memory, visuospatial abilities and verbal fluency.

Results:
As expected, the preclinical AD group performed better than the AD group across most cognitive tests. More interestingly, the effects of low vitamin B12 and folate levels were negligible across all cognitive tests in clinical and preclinical AD.

Conclusion: 
These findings suggest that the influence of vitamin B deficiency on cognitive functioning is overshadowed by the neurodegenerative processes associated with AD.

Keyword Cognition
Comorbidity
Dementia
Population-based
Vitamin B12
Folate
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published online: November 19, 2007

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Tue, 19 Jan 2010, 16:00:22 EST by Gerald Martin on behalf of Faculty Of Health Sciences