Olfactory functions in asymptomatic carriers of the Huntington disease mutation

Larsson, Maria, Lundin, Anders and Robins Wahlin, Tarja-Brita (2006) Olfactory functions in asymptomatic carriers of the Huntington disease mutation. Journal of Clinical and Experimental Neuropsychology, 28 8: 1373-1380. doi:10.1080/13803390500473746

Author Larsson, Maria
Lundin, Anders
Robins Wahlin, Tarja-Brita
Title Olfactory functions in asymptomatic carriers of the Huntington disease mutation
Journal name Journal of Clinical and Experimental Neuropsychology   Check publisher's open access policy
ISSN 1380-3395
Publication date 2006-12
Sub-type Article (original research)
DOI 10.1080/13803390500473746
Volume 28
Issue 8
Start page 1373
End page 1380
Total pages 8
Place of publication East Sussex, United Kingdom
Publisher Psychology Press
Language eng
Subject 1701 Psychology
Abstract Huntington's disease (HD) is a neurodegenerative disorder initially affecting the basal ganglia and especially the head of the caudate nucleus. Neuropsychological research has indicated that olfactory dysfunction may appear early in HD, prior to the onset of significant motor or cognitive dysfunction. The aim of this study was to examine whether asymptomatic carriers of the Huntington disease mutation also exhibit olfactory dysfunction. To address this issue we presented an extensive olfactory test battery comprising tasks assessing olfactory sensitivity, intensity discrimination, quality discrimination, episodic odor memory, and odor identification, to a group of gene carriers and nonmutation carriers of the disease. The results showed that gene carriers were selectively impaired in discriminating odor quality, although performance did not differ from noncarriers across the other tasks. The role played by striatum and then in particular the caudate nucleus for olfactory processing in general, and for odor quality discrimination in particular, is discussed.
Keyword Extrapyramidal syndrome
Huntington disease
Huntington chorea
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 19 Jan 2010, 15:11:05 EST by Jon Swabey on behalf of Faculty Of Health Sciences