CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium

Ruitenberg, Marc J., Vukovic, Jana, Blomster, Linda, Hall, Jarrad M, Jung, Steffen, Filgueira, Luis, McMenamin, Paul G. and Plant, Giles W. (2008) CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium. Journal of Neuroimmunology, 205 1-2: 80-85. doi:10.1016/j.jneuroim.2008.09.010


Author Ruitenberg, Marc J.
Vukovic, Jana
Blomster, Linda
Hall, Jarrad M
Jung, Steffen
Filgueira, Luis
McMenamin, Paul G.
Plant, Giles W.
Title CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium
Journal name Journal of Neuroimmunology   Check publisher's open access policy
ISSN 0165-5728
1872-8421
Publication date 2008-12-01
Sub-type Article (original research)
DOI 10.1016/j.jneuroim.2008.09.010
Volume 205
Issue 1-2
Start page 80
End page 85
Total pages 6
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject 11 Medical and Health Sciences
1107 Immunology
Abstract The olfactory epithelium (OE) is a site of massive adult neurogenesis where olfactory sensory neurons (OSNs) are continuously turned over. Tissue macrophages have been implicated in phagocytosis of degenerating cells but the molecular mechanisms that allow for their recruitment while maintaining a neurogenic microenvironment are poorly understood. This study reports that the neuroprotective chemokine CX3CL1 is expressed by OSNs and olfactory ensheathing cells. Monocyte-derived cells in the OE depend on CX3CL1-signalling for intraepithelial migration and apical dendrite expression. These observations are first to demonstrate phenotypic differences in appearance and distribution of monocyte-derived cells in nervous tissue due to CX3CR1 deficiency.
Keyword Olfactory Sensory Neurons
Neurogenic microenvironment
CX3CR1
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
School of Biomedical Sciences Publications
 
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