Treatment disparities and effect on late mortality in patients with diabetes presenting with acute myocardial infarction: observations from the ACACIA registry

Hung, Joseph, Brieger, David B., Amerena, John V., Coverdale, Steven G., Rankin, James M., Astley, Carolyn M., Soman, Ashish and Chew, Derek P. (2009) Treatment disparities and effect on late mortality in patients with diabetes presenting with acute myocardial infarction: observations from the ACACIA registry. Medical Journal of Australia, 191 10: 539-543.


Author Hung, Joseph
Brieger, David B.
Amerena, John V.
Coverdale, Steven G.
Rankin, James M.
Astley, Carolyn M.
Soman, Ashish
Chew, Derek P.
Title Treatment disparities and effect on late mortality in patients with diabetes presenting with acute myocardial infarction: observations from the ACACIA registry
Journal name Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
1326-5377
Publication date 2009-11
Sub-type Article (original research)
Volume 191
Issue 10
Start page 539
End page 543
Total pages 5
Place of publication Sydney, Australia
Publisher Australasian Medical Publishing Co.
Language eng
Subject 11 Medical and Health Sciences
Formatted abstract
Objectives:

To compare the use of evidence-based pharmacological and invasive treatments and 12-month mortality rates between patients with and without diabetes who present with acute myocardial infarction (MI), and to explore the relationship between these treatments and late clinical outcomes.

Design and setting:


Prospective, nationwide multicentre registry: the Acute Coronary Syndrome Prospective Audit (ACACIA).

Patients:


Patients presenting to 24 metropolitan and 15 non-metropolitan hospitals with acute coronary syndrome (ACS) and a final discharge diagnosis of acute MI between November 2005 and July 2007.

Main outcome measure:


All-cause mortality at 12 months.

Results:


Nearly a quarter of 1744 patients with a final diagnosis of acute MI had a history of diabetes on presentation. Patients with diabetes were older, with a greater prevalence of comorbidities than non-diabetic patients, and were less likely to be treated at discharge with evidence-based medications (aspirin, clopidogrel, a statin and/or a β-blocker) or to receive early invasive procedures. After adjusting for baseline characteristics and therapeutic interventions, diabetes at presentation was independently associated with a higher mortality at 12 months after MI (hazard ratio, 1.79; 95% CI, 1.18–2.72; P = 0.007). Early invasive management and discharge prescription of guideline-recommended medications were associated with a significantly reduced hazard of mortality at 12 months.

Conclusion:


Patients with diabetes have a higher risk than non-diabetic patients of late mortality following an acute MI, yet receive fewer guideline-recommended medications and early invasive procedures. Increased application of proven pharmacotherapies and an early invasive management strategy in patients with diabetes presenting with ACS might improve their outcomes.

Study protocol number (sanofi-aventis):


PML-0051.

Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Sun, 17 Jan 2010, 00:04:10 EST