Acute renal failure in patients on diuretics and/or NSAID, COX-2 inhibitors, ACEI, ARA

Ng, Chin Soon, Pillans, Peter I., Johnson, David W. and Sturtevant, Joanna M. (2008) Acute renal failure in patients on diuretics and/or NSAID, COX-2 inhibitors, ACEI, ARA. Journal of Pharmacy Practice and Research, 38 4: 280-282.

Author Ng, Chin Soon
Pillans, Peter I.
Johnson, David W.
Sturtevant, Joanna M.
Title Acute renal failure in patients on diuretics and/or NSAID, COX-2 inhibitors, ACEI, ARA
Journal name Journal of Pharmacy Practice and Research   Check publisher's open access policy
ISSN 1445-937X
Publication date 2008-12
Sub-type Article (original research)
Volume 38
Issue 4
Start page 280
End page 282
Total pages 3
Place of publication Collingwood, VIC, Australia
Publisher Society of Hospital Pharmacists of Australia
Language eng
Subject 110312 Nephrology and Urology
Formatted abstract Aim:
To review acute renal failure in patients on one or more target drugs - diuretics, non-steroidal anti-inflammatory drugs (NSAID), cyclo-oxygenase-2 (COX-2) inhibitors, angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor antagonists (ARA).

Method:
Retrospective review of drug charts of patients admitted to hospital with acute renal failure from 2003 to 2005. Patients taking one or more of the target drugs prior to admission were identified. Data were collected on patient demographics, target drugs, other factors contributing to acute renal failure, medical history, baseline and peak creatinine concentration, and clinical outcome. The baseline and lowest estimated glomerular filtration rate (eGFR) were calculated.

Results:
Of the 289 patients admitted with acute renal failure, 108 (37%) were taking one or more of the target drugs. The mean age was 73 years and 84 patients (79%) had a baseline eGFR of d 60 mL/min. There was a marked decline in kidney function from a mean baseline eGFR of 50 mL/min to 17 mL/ min (60% decline). 44% of patients were dehydrated, 12% were septic and 60% had more than 4 comorbid diseases. Only 6 patients were on more than 3 target drugs. The decline in eGFR exceeded 50% with each drug/drug combination and except for ACEI and ARA (withheld in 50% of cases) other drugs/drug combinations were withheld in most patients. Acute renal failure was reversible after treatment of the underlying illness and withdrawal of the target drugs in the majority of patients.

Conclusion:
Over a third of patients with acute renal failure were taking diuretics, NSAID/COX-2 inhibitors, ACEI/ARA, which may have played a causal or contributory role in the decline in their renal function. Other risk factors for developing acute renal failure included dehydration, sepsis, multiple comorbidities and older age.
Keyword Acute renal failure
Kidneys -- Wounds and injuries
Enzyme inhibitors -- Therapeutic use
Anti-inflammatory agents -- Side effects
Kidneys -- Effect of drugs on
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 14 Jan 2010, 16:30:10 EST by Maria Campbell on behalf of Faculty Of Health Sciences