Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: A position statement

The Australasian Creatinine Consensus Working Group and Johnson, David (2005) Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: A position statement. The Clinical Biochemist Reviews, 26 3: 81-86.


Author The Australasian Creatinine Consensus Working Group
Johnson, David
Title Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: A position statement
Journal name The Clinical Biochemist Reviews   Check publisher's open access policy
ISSN 0159-8090
Publication date 2005-08
Sub-type Article (original research)
Volume 26
Issue 3
Start page 81
End page 86
Total pages 6
Place of publication Mt. Lawley, W.A.
Publisher Australasian Association of Clinical Biochemists
Language eng
Subject 110312 Nephrology and Urology
Formatted abstract
• The systematic staging of chronic kidney disease (CKD) by glomerular filtration measurement and proteinuria has allowed the development of rational and appropriate management plans.
• One of the barriers to early detection of CKD is the lack of a precise, reliable and consistent measure of kidney function.
• The most common measure of kidney function is currently serum creatinine concentration. It varies with age, sex, muscle mass and diet, and interlaboratory variation between measurements is as high as 20%.
• The reference interval for serum creatinine concentration includes up to 25% of people (particularly thin, elderly women) who have an estimated glomerular filtration rate (eGFR) that is signifi cantly reduced (< 60 mL/min/1.73m2).
• The recent publication of a validated formula (MDRD) to estimate GFR from age, sex, race and serum creatinine concentration, without any requirement for measures of body mass, allows pathology laboratories to “automatically” generate eGFR from data already acquired.
• Automatic laboratory reporting of eGFR calculated from serum creatinine measurements would help to identify asymptomatic kidney dysfunction at an earlier stage.
• eGFR correlates well with complications of CKD and an increased risk of adverse outcomes such as cardiovascular morbidity and mortality.
• We recommend that pathology laboratories automatically report eGFR each time a serum creatinine test is ordered in adults.
• As the accuracy of eGFR is suboptimal in patients with normal or near-normal renal function, we recommend that calculated eGFRs above 60 mL/min/1.73m2 be reported by laboratories as ‘‘> 60 mL/min/1.73m2 ”, rather than as a precise figure.
Keyword Chronic kidney disease
CKD
glomerular filtration measurement
proteinuria
automatic reporting
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 14 Jan 2010, 15:27:27 EST by Maria Campbell on behalf of Faculty Of Health Sciences