Dissociable neural circuits for encoding and retrieval of object locations during active navigation in humans

Baumann, Oliver, Chan, Edgar and Mattingley, Jason B. (2010) Dissociable neural circuits for encoding and retrieval of object locations during active navigation in humans. NeuroImage, 49 3: 2816-2825. doi:10.1016/j.neuroimage.2009.10.021


Author Baumann, Oliver
Chan, Edgar
Mattingley, Jason B.
Title Dissociable neural circuits for encoding and retrieval of object locations during active navigation in humans
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2010-02-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2009.10.021
Volume 49
Issue 3
Start page 2816
End page 2825
Total pages 9
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2011
Language eng
Subject C1
170205 Neurocognitive Patterns and Neural Networks
970117 Expanding Knowledge in Psychology and Cognitive Sciences
970106 Expanding Knowledge in the Biological Sciences
920111 Nervous System and Disorders
Abstract Several cortical and subcortical circuits have been implicated in object location memory and navigation. Uncertainty remains, however, about which neural circuits are involved in the distinct processes of encoding and retrieval during active navigation through three-dimensional space. We used functional magnetic resonance imaging (fMRI) to measure neural responses as participants learned the location of a single target object relative to a small set of landmarks. Following a delay, the target was removed and participants were required to navigate back to its original position. The relative and absolute locations of landmarks and the target object were changed on every trial, so that participants had to learn a novel arrangement for each spatial scene. At encoding, greater activity within the right hippocampus and the parahippocampal gyrus bilaterally predicted more accurate navigation to the hidden target object in the retrieval phase. By contrast, during the retrieval phase, more accurate performance was associated with increased activity in the left hippocampus and the striatum bilaterally. Dividing participants into good and poor navigators, based upon behavioural performance, revealed greater striatal activity in good navigators during retrieval, perhaps reflecting superior procedural learning in these individuals. By contrast, the poor navigators showed stronger left hippocampal activity, suggesting reliance on a less effective verbal or symbolic code by this group. Our findings suggest separate neural substrates for the encoding and retrieval stages of object location memory during active navigation, which are further modulated by participants' overall navigational ability. © 2009 Elsevier Inc. All rights reserved.
Keyword Navigation
fMRI
Memory
Hippocampus
Parahippocampal gyrus
Striatum
Basal ganglia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 42 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 14 Jan 2010, 15:22:39 EST by Debra McMurtrie on behalf of Queensland Brain Institute