Patterns of recurrence and disease-free survival in advanced squamous cell carcinoma of the vulva

Lataifeh, Isam, Nascimento, Marcelo Carraro, Nicklin,James L., Perrin, Lewis C., Crandon, Alex J. and Obermair, Andreas (2004) Patterns of recurrence and disease-free survival in advanced squamous cell carcinoma of the vulva. Gynecologic oncology, 95 3: 701-705. doi:10.1016/j.ygyno.2004.08.015

Author Lataifeh, Isam
Nascimento, Marcelo Carraro
Nicklin,James L.
Perrin, Lewis C.
Crandon, Alex J.
Obermair, Andreas
Title Patterns of recurrence and disease-free survival in advanced squamous cell carcinoma of the vulva
Journal name Gynecologic oncology   Check publisher's open access policy
ISSN 0090-8258
Publication date 2004
Sub-type Article (original research)
DOI 10.1016/j.ygyno.2004.08.015
Volume 95
Issue 3
Start page 701
End page 705
Total pages 5
Place of publication New York, United States
Publisher Academic Press
Language eng
Subject 1112 Oncology and Carcinogenesis
Formatted abstract
Objective. To compare patterns of recurrence and disease-free survival (DFS) of  node-positive and node-negative patients with advanced vulval squamous cell carcinoma (SCC).

Methods. Fifty-five patients with FIGO stage III/IVA vulval SCC who had surgery at the  Queensland Centre for Gynaecological Cancer from 1989 to 1999 were included. Patients were grouped as follows: Group A, pT3 N0; Group B, pT3 N1; Group C, pT4 N2. Treatment included surgery F postoperative radiotherapy. Multivariate Cox models were  calculated to identify independent prognostic factors.

Results. After a median follow-up of 96 months, 25 patients (45.5%) experienced  recurrence at the vulva (n = 2), pelvis (n = 8), or distant sites (n = 15). Recurrence in  the pelvis and at distant sites was more likely for patients in groups B and C ( P0.003). At 5 years the probability of DFS was 66.6%, 35.3%, and 39.8% for patients in groups A, B, and C, respectively  (P0.085). Patients with negative nodes (n = 15), one microscopic positive node (n = 11), and two or more positive nodes (n = 29) had a  probability of DFS of 66.6%, 67.3%, and 26.1% at 5 years, respectively ( P 0.005).

Conclusion. Patients with ≥ 2 positive groin nodes are at risk for distant failure. The  DFS of patients with negative groin nodes and those with only one microscopic  positive node is very similar. The prognosis of patients with  ≥ 2 positive unilateral or bilateral groin nodes is similar. The current FIGO staging system inaccurately reflects prognosis for patients  with advanced vulval cancer. Clinical trials are warranted to investigate the benefit of systemic treatment.
© 2004 Elsevier Inc. All rights reserved.
Keyword Disease-free survival
Squamous cell carcinoma
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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