Should we prefer different drugs to treat hypertension in older and younger adults? Practical implications of clinical trials: American perspective

Pimenta, Eduardo and Oparil, Suzanne (2008) Should we prefer different drugs to treat hypertension in older and younger adults? Practical implications of clinical trials: American perspective. Polskie Archiwum Medycyny Wewnetrznej, 118 9: 508-512.

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Author Pimenta, Eduardo
Oparil, Suzanne
Title Should we prefer different drugs to treat hypertension in older and younger adults? Practical implications of clinical trials: American perspective
Language of Title eng
Journal name Polskie Archiwum Medycyny Wewnetrznej   Check publisher's open access policy
Translated journal name Polish Archives of Internal Medicine
Language of Journal Name pol
eng
ISSN 0032-3772
1897-9483
Publication date 2008-09
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 118
Issue 9
Start page 508
End page 512
Total pages 5
Place of publication Krakow, Poland
Publisher Medycyna Praktyczna
Language pol
eng
Subject 1103 Clinical Sciences
Formatted abstract
Whether older and younger persons derive similar benefit from antihypertensive treatment and whether treatment choices should be tailored to the age of the patient are unresolved issues about which there is a paucity of evidence. The Blood Pressure Lowering Treatment Trialists' Collaboration has attempted to address this deficiency in a meta-analysis that included 31 trials with 190,606 participants. They compared the proportionate risk reductions achieved with different classes of antihypertensive drugs in younger (< 65 years) and older (> 65 years) adults. They reported that there was no clear evidence to support recommendations for particular antihypertensive drug classes in older or younger adults. In this paper we discussed the Trialists' paper and its limitations and strenghts, current guidelines recommendations, and the major conclusions that are important for clinicians.

Keyword Age factors
Angiotensin II type 1 receptor blockers/therapeutic use
Angiotensin-converting enzyme inhibitors/therapeutic use
Antihypertensive agents - pharmacology
Antihypertensive agents - therapeutic use
Blood pressure - drug effects
Calcium channel blockers - therapeutic use
Harm reduction
Heart failure - prevention & control
Hypertension - drug therapy
Cardiovascular Risk
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 14 Jan 2010, 15:08:06 EST by June Temby on behalf of Faculty Of Health Sciences