Hodgkin’s lymphoma in children aged 5 years or less – The United Kingdom experience

Stoneham, S., Ashley, S., Pinkerton, Ross, Hewitt, Martin, Wallace,W. H. B. and Shankara, A. G. (2007) Hodgkin’s lymphoma in children aged 5 years or less – The United Kingdom experience. European Journal of Cancer, 43 9: 1415-1421. doi:10.1016/j.ejca.2007.03.013


Author Stoneham, S.
Ashley, S.
Pinkerton, Ross
Hewitt, Martin
Wallace,W. H. B.
Shankara, A. G.
Title Hodgkin’s lymphoma in children aged 5 years or less – The United Kingdom experience
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
Publication date 2007-06
Sub-type Article (original research)
DOI 10.1016/j.ejca.2007.03.013
Volume 43
Issue 9
Start page 1415
End page 1421
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Elsevier Sci Ltd
Language eng
Subject 1110 Nursing
1112 Oncology and Carcinogenesis
Formatted abstract
Purpose: The aim of this study is to describe the natural history of Hodgkin’s  Lymphoma (HL) in a larg unselected group of children aged 5 years or below at diagnosis, who were  treated on a standard treatment programme in the United Kingdom between 1982 and 2000.

Methods:
Eighty-one unselected children with HL aged 5 years or under at diagnosis,  treated on the United Kingdom Children’s Cancer Study Group (UKCCSG) Hodgkin’s trials  HD1 (1982–1992) and HD2 (1992–2000), were included in the study.

Results:
Sixty-one patients (81%) presented with early stage disease (n = 66).  Fifty-three patients (65%) received combination chemotherapy, 28 (34%) received  involved field  radiotherapy (IF-RT) and 4 patients were treated with combined  modality  therapy.  Eighteen children relapsed after primary therapy.

Conclusions: Children treated with IF-RT had a higher rate of primary treatment  failures as well as increased late treatment-related morbidity.
©2007 Published by Elsevier Ltd.
Keyword Hodgkin’s lymphoma
Young children
Hypothyroidism
Radiotherapy
Relapses
Survival
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 14 Jan 2010, 10:30:55 EST by Simon Utteridge on behalf of Faculty Of Health Sciences