Acute neurotoxicity in children with advanced stage B-non-Hodgkin’s lymphoma and B-acute lymphoblastic leukaemia treated with the United Kingdom children cancer study group 9002/9003 protocols

Atra, A., Pinkerton, C. R., Bouffet, E., Norton, A., Hobson, R., Imeson, J. D. and Gerrard, M. (2004) Acute neurotoxicity in children with advanced stage B-non-Hodgkin’s lymphoma and B-acute lymphoblastic leukaemia treated with the United Kingdom children cancer study group 9002/9003 protocols. European Journal of Cancer, 40 9: 1346-1350.


Author Atra, A.
Pinkerton, C. R.
Bouffet, E.
Norton, A.
Hobson, R.
Imeson, J. D.
Gerrard, M.
Title Acute neurotoxicity in children with advanced stage B-non-Hodgkin’s lymphoma and B-acute lymphoblastic leukaemia treated with the United Kingdom children cancer study group 9002/9003 protocols
Journal name European Journal of Cancer  (ERA 2012 Listed)    (ERA 2010 Rank A)   Check publisher's open access policy
Publication date 2004-06
Sub-type Article
DOI 10.1016/j.ejca.2004.02.011
Volume number 40
Issue number 9
ISSN 0959-8049
Start page 1346
End page 1350
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 1110 Nursing
1112 Oncology and Carcinogenesis
Formatted abstract We reviewed the pattern of acute neurotoxicity in children with B-non-Hodgkin's lymphoma (B-NHL) and B-acute lymphoblastic leukaemia (ALL) treated with the UKCCSG 9002/9003 protocols. Among 175 patients, 21 (12%) developed acute neurotoxicity: 9002 protocol (n=11/112) and 9003 (n=10/63). There were 20 boys and the median age was 10 years. Patients with neurological symptoms due to other causes were excluded. Acute neurological symptoms developed following induction chemotherapy in 7 patients, or after a more intensive course of chemotherapy containing high-dose methotrexate (n=14). Nine patients required their chemotherapy to be altered because of the acute neurotoxicity. One patient died of cerebral haemorrhage but none of the remaining six deaths was attributed to acute neurotoxicity. We conclude that acute neurotoxicity is common in children treated with the 9002/9003 protocols and tends to be transient. Intrathecal and systemic chemotherapy including high-dose methotrexate is probably the most common predisposing factor. Modification of subsequent chemotherapy is not invariably necessary.
Keyword Acute neurotoxicity
Childhood
Advanced B-NHL
B-ALL
Q-Index Code C1

Document type: Journal Article
Sub-type: Article
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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