Interleukin-6 promoter polymorphism: Risk and pathology of Alzheimer's disease

Zhang, Yong, Hayes, Angela, Pritchard, Antonia, Thaker, Uma, Haque, M. Sayeed, Lemmon, Helen, Harris, Judith, Cumming, Alistair, Lambert, Jean-Charles, Chartier-Harlin, Marie-Christine, St. Clair, David, Iwatsubo, Takeshi, Mann, David M. and Lendon, Corinne L. (2004) Interleukin-6 promoter polymorphism: Risk and pathology of Alzheimer's disease. Neuroscience Letters, 362 2: 99-102. doi:10.1016/j.neulet.2004.03.008

Author Zhang, Yong
Hayes, Angela
Pritchard, Antonia
Thaker, Uma
Haque, M. Sayeed
Lemmon, Helen
Harris, Judith
Cumming, Alistair
Lambert, Jean-Charles
Chartier-Harlin, Marie-Christine
St. Clair, David
Iwatsubo, Takeshi
Mann, David M.
Lendon, Corinne L.
Title Interleukin-6 promoter polymorphism: Risk and pathology of Alzheimer's disease
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
Publication date 2004-05-20
Sub-type Article (original research)
DOI 10.1016/j.neulet.2004.03.008
Volume 362
Issue 2
Start page 99
End page 102
Total pages 4
Place of publication Amsterdam, Netherlands
Publisher Elsevier Ireland
Language eng
Subject 1109 Neurosciences
Formatted abstract
Inflammatory and immune responses are involved in the pathogenesis of Alzheimer's disease (AD). Interleukin-6 (IL-6), an inflammatory cytokine, is thought to play a role in neurodegeneration of the central nervous system and has been associated with increased amyloid precursor protein expression in vitro and greater cognitive decline. Previously a C−174G polymorphism in the promoter of IL-6, which influences expression in vitro, has been found associated in some studies but not all. We investigated this polymorphism in a large independent UK sample of AD cases (n=356) and controls (n=434) but found no association. We extended the study to genotype/phenotype correlations but found no correlation with age of onset (n=338), brain amyloid load (n=126) or Tau load (n=101), brain microglial cell load (n=65) or brain reactive astrocytes (n=127). Our data do not support a pathogenic role in AD for the C−174G polymorphism in isolation.
q 2004 Elsevier Ireland Ltd. All rights reserved.
Keyword Alzheimer's disease
Amyloid load
Microglial cell load
Reactive astrocytes
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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