A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease

Tian, J., Shi, J., Bailey, K., Harris, J. M., Pritchard, A., Lambert, J. C., Chartier-Harlin, M. C., Pickering-Brown, S. M., Lendon, C. L. and Mann, D. M. A. (2004) A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease. Neuroscience Letters, 354 2: 103-106. doi:10.1016/j.neulet.2003.09.072


Author Tian, J.
Shi, J.
Bailey, K.
Harris, J. M.
Pritchard, A.
Lambert, J. C.
Chartier-Harlin, M. C.
Pickering-Brown, S. M.
Lendon, C. L.
Mann, D. M. A.
Title A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
1872-7972
0167-6253
Publication date 2004-01-09
Sub-type Article (original research)
DOI 10.1016/j.neulet.2003.09.072
Volume 354
Issue 2
Start page 103
End page 106
Total pages 4
Place of publication Amsterdam, Netherlands
Publisher Elsevier Ireland
Language eng
Subject 1109 Neurosciences
Abstract The impact of the insertion (I)/deletion (D) (I/D) polymorphism in the angiotensin 1-converting enzyme (ACE) gene on the extent of white matter myelin loss (ML) was investigated in four regions of the cerebral cortex in an autopsy-confirmed series of 93 patients with Alzheimer's disease (AD). The possible influence of APO E ε4 allele acting in concert with ACE D allele was assessed. The extent of ML did not differ between D/D, I/D and I/I genotype groups when data from all four brain regions were combined. However, separate analysis showed that the frontal and temporal cortex tended to be affected more severely by ML in patients with D/D genotype compared to those with I/D and I/I genotypes. Stratification according to APO E ε4 allele revealed a greater overall ML in patients bearing at least one copy of ACE D allele and one APO E ε4 allele, especially in individuals homozygous for both. The APO E ε4 allele may therefore act synergistically in patients with AD (and other subjects) bearing ACE D/D genotype to increase the risk of ML, perhaps through transient ischaemic episodes consequent upon poor cardiac output associated with coronary atherosclerosis in patients with the APO E ε4 allele. © 2003 Elsevier Ireland Ltd. All rights reserved.
Keyword Alzheimer's disease
White matter myelin loss
Angiotensin 1-converting enzyme gene
Apolipoprotein E gene
Polymerase chain reaction
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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