Optimizing therapy for Candida infections

Playford, Elliott Geoffrey and Sorrell, Tania C. (2007) Optimizing therapy for Candida infections. Seminars in Respiratory and Critical Care Medicine, 28 6: 678-688. doi:10.1055/s-2007-996415

Author Playford, Elliott Geoffrey
Sorrell, Tania C.
Title Optimizing therapy for Candida infections
Journal name Seminars in Respiratory and Critical Care Medicine   Check publisher's open access policy
ISSN 1069-3424
Publication date 2007
Sub-type Article (original research)
DOI 10.1055/s-2007-996415
Volume 28
Issue 6
Start page 678
End page 688
Total pages 11
Place of publication New York, NY, United States
Publisher Thieme Medical Publishers
Language eng
Subject 1108 Medical Microbiology
Abstract The problem of invasive candidiasis among ICU patients is an increasing and evolving one. Despite advances in supportive care, increasing numbers of critically ill and vulnerable patients are susceptible to infection, and the clinical consequences for those who do develop invasive candidiasis remain poor. Evolving epidemiological trends, particularly a relative increase in the incidence of fluconazole-resistant Candida spp., have further complicated management. The recent availability of antifungal agents, such as voriconazole, the echinocandins, and lipid-associated amphotericin B preparations, with improved safety profiles, extended spectra, and proven clinical efficacies, offers new therapeutic options. However, optimizing therapy requires the consideration of numerous factors: the differing pharmacological properties of these agents, cost, the clinical status and progress of the patient, estimates of the likelihood of resistance, and microbiological data as they become available. Because early institution of antifungal therapy appears an important determinant of favorable outcome, accurate early microbiological and clinical markers of invasive candidiasis to guide early antifungal interventions are desperately needed and remain an area of active investigation.
Keyword Antifungal Agents/pharmacology
Candida/drug effects
Candida/isolation & purification
Candidiasis/drug therapy
Cross Infection/drug therapy
Cross Infection/microbiology
Drug Resistance, Fungal/drug effects
Equipment Contamination
Intensive Care Units
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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Created: Wed, 13 Jan 2010, 12:05:21 EST by Tara Johnson on behalf of Faculty Of Health Sciences