Apolipoprotein E epsilon4 Allele Frequency and Age at Onset of Alzheimer’s Disease

Davidson, Yvonne, Gibbons, Linda, Pritchard, Antonia, Hardicre, Jayne, Wren, Joanne, Stopford, Cheryl, Julien, Camille, Thompson, Jennifer, Payton, Antony, Pickering-Brown, Stuart M., Pendleton, Neil, Horan, Michael A., Burns, Alistair, Purandare, Nitin, Lendon, Corinne L., Neary, David, Snowden, Julie S. and Mann, David M. A. (2006) Apolipoprotein E epsilon4 Allele Frequency and Age at Onset of Alzheimer’s Disease. Dementia and Geriatric Cognitive Disorders, 23 1: 60-66. doi:10.1159/000097038

Author Davidson, Yvonne
Gibbons, Linda
Pritchard, Antonia
Hardicre, Jayne
Wren, Joanne
Stopford, Cheryl
Julien, Camille
Thompson, Jennifer
Payton, Antony
Pickering-Brown, Stuart M.
Pendleton, Neil
Horan, Michael A.
Burns, Alistair
Purandare, Nitin
Lendon, Corinne L.
Neary, David
Snowden, Julie S.
Mann, David M. A.
Title Apolipoprotein E epsilon4 Allele Frequency and Age at Onset of Alzheimer’s Disease
Formatted title
Apolipoprotein E ε4 Allele Frequency and Age at Onset of Alzheimer’s Disease
Journal name Dementia and Geriatric Cognitive Disorders   Check publisher's open access policy
ISSN 1420-8008
Publication date 2006-12
Sub-type Article (original research)
DOI 10.1159/000097038
Volume 23
Issue 1
Start page 60
End page 66
Total pages 7
Place of publication Basel, Switzerland
Publisher S. Karger
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
The age distribution of the ε4 allelic form of the apolipoprotein E gene (APOE) was investigated in 630 patients with Alzheimer's disease (AD) with onset age ranging from 35 to 90 years. Overall, mean age at onset in APOE ε4 allele bearers was significantly later than that in nonbearers. However, when stratified into early onset AD (EOAD) and late onset (LOAD) groups, mean age at onset in EOAD cases bearing APOE ε4 allele was later than that in those EOAD cases without ε4 allele, whereas in LOAD mean age at onset in cases bearing APOE ε4 allele was earlier than in those without ε4 allele. When analysed by decade, it was observed that 37% of the total number of APOE ε4 allele bearers, and 43% of total number of cases with APOE ε4/ε4 genotype fell into the 60-69 years age class. Hence, APOE ε4 allele frequency, at 0.44, was highest in the 60-69 years age class, progressively decreasing either side of this age group. APOE ε4 allele therefore has its maximum impact between onset ages of between 60 and 70 years.
Copyright © 2007 S. Karger AG, Basel
Keyword Alzheimer's disease
Apolipoprotein E gene
ε4 allele
epsilon4 allele
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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