Investigation of the role of the dopamine transporter in susceptibility to behavioural and psychological symptoms of patients with probable Alzheimer's Disease

Pritchard, Antonia L., Pritchard, Colin W., Bentham, Peter and Lendon, Corinne L. (2008) Investigation of the role of the dopamine transporter in susceptibility to behavioural and psychological symptoms of patients with probable Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders, 26 3: 257-260. doi:10.1159/000160958


Author Pritchard, Antonia L.
Pritchard, Colin W.
Bentham, Peter
Lendon, Corinne L.
Title Investigation of the role of the dopamine transporter in susceptibility to behavioural and psychological symptoms of patients with probable Alzheimer's Disease
Journal name Dementia and Geriatric Cognitive Disorders   Check publisher's open access policy
ISSN 1420-8008
1421-9824
Publication date 2008-10
Sub-type Article (original research)
DOI 10.1159/000160958
Volume 26
Issue 3
Start page 257
End page 260
Total pages 4
Place of publication Basel, Switzerland
Publisher S. Karger
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
Background/Aims:
Alzheimer's disease patients commonly suffer from behavioural and psychological symptoms of dementia (BPSD); a genetic component to the development of BPSD has been demonstrated. Genetic risk factors for other psychiatric disorders have been implicated in BPSD; however, this is the first known investigation of the dopamine transporter (DAT1) gene in BPSD.

Methods:
Our large cohort of 395 patients with probable Alzheimer's disease was dichotomised into whether they had ever suffered from a given symptom over the study period or not, based on longitudinal data using the BPSD (Neuropsychiatric Inventory). These measures were related to the DAT1 3´-untranslated region (UTR) variable number tandem repeat (VNTR) polymorphism.

Results:
Potential associations were revealed between the 9-repeat allele and presence of irritability and between the 10-repeat allele and aberrant motor behaviour (AMB); however, these do not remain significant after correction for multiple testing. No associations were observed with delusions, hallucinations, depression, agitation/aggression or elation.

Conclusion:
Our data suggest that the DAT1 3´-UTR VNTR could play a role in susceptibility to irritability and AMB. The findings presented here require replication in large well-characterised cohorts.

Copyright © 2008 S. Karger AG, Basel
Keyword Alzheimer's disease
Dopamine transporter 1
Psychosis
Depression
Aggression
Dopamine
Elation/mania
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 13 Jan 2010, 09:05:54 EST by Jon Swabey on behalf of Faculty Of Health Sciences