The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

Canna, K., Hilmy, M., McMillan, D. C., Smith, G. W., McKee, R. F., McArdle, C. S. and McNicol, A.-M. (2008) The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. Colorectal Disease, 10 7: 663-667. doi:10.1111/j.1463-1318.2007.01416.x


Author Canna, K.
Hilmy, M.
McMillan, D. C.
Smith, G. W.
McKee, R. F.
McArdle, C. S.
McNicol, A.-M.
Title The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer
Journal name Colorectal Disease   Check publisher's open access policy
ISSN 1462-8910
1463-1318
Publication date 2008-09
Year available 2007
Sub-type Article (original research)
DOI 10.1111/j.1463-1318.2007.01416.x
Volume 10
Issue 7
Start page 663
End page 667
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
Background:
The aim of the present study was to examine the relationship between Ki-67, C-reactive protein and cancer-specific survival in patients undergoing resection for colorectal cancer.
Method:
One hundred and forty-seven patients undergoing potentially curative resection for colorectal cancer had preoperative C-reactive protein concentrations and tumour Ki-67 labelling index measured.
Results:
On univariate analysis, age (P < 0.001), Dukes stage (P < 0.001), C-reactive protein (P < 0.001) and expression of Ki-67 (< 0.01) were associated with poorer cancer-specific survival. Ki-67 labelling index and Creactive protein were correlated (rs = 0.172, P = 0.037). On multivariate analysis, age (HR 1.96, 95% CI 1.26– 3.04, P = 0.003), Dukes stage (HR 4.38, 95% CI 2.11– 9.09, P < 0.001) and C-reactive protein (HR 4.09, 95% CI 2.04–8.24, P < 0.001) retained significance.
Conclusion:
Increased tumour proliferation is associated with a systemic inflammatory response and poor cancerspecific survival in patients undergoing potentially curative surgery for colorectal cancer.
© 2007 The Association of Coloproctology of Great Britain and Ireland

Keyword Colorectal cancer
Ki-67
C-reactive protein
Cancer survival
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published Online:14 Nov 2007

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 12 Jan 2010, 12:36:33 EST by Natalie Holt on behalf of Faculty Of Health Sciences