The effect of the Hyper-CVAD chemotherapy regimen on fertility and ovarian function

Seshadri, T., Hourigan, M. J., Wolf, M., Mollee, P. N. and Seymour, J. F. (2006) The effect of the Hyper-CVAD chemotherapy regimen on fertility and ovarian function. Leukemia Research, 30 4: 483-485. doi:10.1016/j.leukres.2005.08.014


Author Seshadri, T.
Hourigan, M. J.
Wolf, M.
Mollee, P. N.
Seymour, J. F.
Title The effect of the Hyper-CVAD chemotherapy regimen on fertility and ovarian function
Journal name Leukemia Research   Check publisher's open access policy
ISSN 0145-2126
1873-5835
Publication date 2006-04
Year available 2005
Sub-type Article (original research)
DOI 10.1016/j.leukres.2005.08.014
Volume 30
Issue 4
Start page 483
End page 485
Total pages 3
Editor John M. Bennett
Terry J. Hamblin
Place of publication Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 1103 Clinical Sciences
Abstract Hyper-CVAD is a dose intensive chemotherapy regimen that has been used successfully in lymphoblastic lymphoma and leukaemia. However, the effect on ovarian function has not been evaluated. Thus, we undertook a retrospective analysis of patients under 40 years of age who had Hyper-CVAD as initial therapy and documented ovarian function as defined by regular menstruation off hormonal agents or naturally conceiving. Of the 12 patients identified, 7 were evaluable. Median age was 25. Six patients had resumption of regular menstruation and three of these women have conceived naturally. In conclusion, resumption of normal fertility is probable post-treatment with Hyper-CVAD. © 2005 Elsevier Ltd. All rights reserved.
Keyword Hyper-CVAD chemotherapy
Fertility
Ovarian function
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Available online 19 September 2005

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Tue, 12 Jan 2010, 11:46:05 EST by Simon Utteridge on behalf of Faculty Of Health Sciences