STAT5A/B activity is required in the developing forebrain and spinal cord

Markham, Kathryn, Schuurmans, Carol and Weiss, Samuel (2007) STAT5A/B activity is required in the developing forebrain and spinal cord. Molecular and Cellular Neuroscience, 35 2: 272-282. doi:10.1016/j.mcn.2007.03.001


Author Markham, Kathryn
Schuurmans, Carol
Weiss, Samuel
Title STAT5A/B activity is required in the developing forebrain and spinal cord
Journal name Molecular and Cellular Neuroscience   Check publisher's open access policy
ISSN 1044-7431
1095-9327
Publication date 2007-06
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.mcn.2007.03.001
Volume 35
Issue 2
Start page 272
End page 282
Total pages 11
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Subject 1109 Neurosciences
1114 Paediatrics and Reproductive Medicine
111401 Foetal Development and Medicine
Abstract Formation of the CNS requires the coordination and integration of processes such as cell proliferation, neuronal differentiation, neuronal migration, axon tract formation and synaptogenesis, all of which must occur at precise times and places during development. Although growth factors are known to play a role in regulating many of these processes, very little is known of the signaling events immediately downstream of ligand–receptor interactions in the developing CNS. Here we present evidence that STAT5, an important mediator of cytokine signaling, is required for some aspects of CNS development. We show that phosphorylated and hence activated forms of STAT5 (pSTAT5) are expressed in a temporally restricted manner in a subset of early-born telencephalic neurons and axons. Accordingly, Stat5 mutants have zone, suggestive of migration defects. Moreover, corticofugal axons develop aberrantly in Stat5 mutants, indicative of a role for pSTAT5 in axon guidance. Notably, pSTAT5 is also expressed in commissural axons in the embryonic spinal cord, where it is also required for their guidance. Taken together, we provide the first evidence that STAT5 is a key effector molecule in the developing mammalian CNS.
Keyword Nervous system
Telencephalon
Spinal cord
Development; Axon tracts
Neurogenesis
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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Created: Mon, 11 Jan 2010, 15:07:04 EST by Macushla Boyle on behalf of Faculty Of Health Sciences