Impact of cytokine gene polymorphisms on graft-vs-host disease

Markey, K. A., MacDonald, K. P. A. and Hill, G. R. (2008) Impact of cytokine gene polymorphisms on graft-vs-host disease. Tissue Antigens, 72 6: 507-516. doi:10.1111/j.1399-0039.2008.01139.x

Author Markey, K. A.
MacDonald, K. P. A.
Hill, G. R.
Title Impact of cytokine gene polymorphisms on graft-vs-host disease
Journal name Tissue Antigens   Check publisher's open access policy
ISSN 0001-2815
Publication date 2008-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1399-0039.2008.01139.x
Open Access Status
Volume 72
Issue 6
Start page 507
End page 516
Total pages 10
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell
Language eng
Subject 11 Medical and Health Sciences
1103 Clinical Sciences
Abstract Allogeneic hematopoietic stem cell transplantation (SCT) remains the only available curative therapy for hematological malignancy. It does, however, result in significant morbidity and mortality, predominantly as a consequence of infections, leukemic relapse and graft-vs-host disease (GVHD). While differences in human leukocyte antigen (HLA) molecules between donor and host make a crucial contribution to the alloreactivity driving the donor–antihost response, the cytokine milieu consisting of molecules that both promote and regulate the alloresponse after transplantation is also critical. As such, genetic studies correlating donor and/or host cytokine polymorphisms with disease outcomes have provided useful insight into disease pathogenesis, often confirming effects that have been dissected in animal models of the disease. It is now clear that the polymorphic expression of key cytokines (particularly tumor necrosis factor and interleukin 10) has a demonstrable effect on disease outcome and overall transplant-related mortality. Consideration of the role of genetic polymorphisms in GVHD severity and procedural mortality associated with SCT will lead to improvements in patient outcome such that the addition of non-HLA genetic typing of potential donors will allow optimization of donor selection for a given recipient. This review provides a discussion of the current state of the literature regarding polymorphic expression of the key GVHD cytokines and their capacity to predict clinical disease outcome.
Keyword Cytokine effectors
Genetic polymorphisms
Graft-vs-host disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Mon, 11 Jan 2010, 13:38:33 EST by Ms May Balasaize on behalf of Faculty Of Health Sciences