Breeding for QX disease resistance negatively selects one form of the defensive enzyme, phenoloxidase, in Sydney rock oysters

Bezemer, Britt, Butt, Daniel, Nell, John, Adlard, Robert and Raftos, David (2006) Breeding for QX disease resistance negatively selects one form of the defensive enzyme, phenoloxidase, in Sydney rock oysters. Fish & Shellfish Immunology, 20 4: 627-636. doi:10.1016/j.fsi.2005.08.007


Author Bezemer, Britt
Butt, Daniel
Nell, John
Adlard, Robert
Raftos, David
Title Breeding for QX disease resistance negatively selects one form of the defensive enzyme, phenoloxidase, in Sydney rock oysters
Journal name Fish & Shellfish Immunology   Check publisher's open access policy
ISSN 1050-4648
Publication date 2006
Sub-type Article (original research)
DOI 10.1016/j.fsi.2005.08.007
Volume 20
Issue 4
Start page 627
End page 636
Total pages 10
Place of publication United Kingdom
Publisher Academic Press
Language eng
Subject 0704 Fisheries Sciences
Formatted abstract
QX disease in Sydney rock oysters (Saccostrea glomerata) is caused by the  paramyxean protozoan, Marteilia sydneyi. Disease outbreaks occur during summer (January to May) and can result in up to 95%  mortality. The New South Wales Department of Primary Industries has been selectively breeding S. glomerata for resistance to QX disease  since 1996. Previous work suggests that this breeding program has specifically affected the defensive phenoloxidase enzyme  system of oysters. The current study more thoroughly characterises the effect of selection on the different forms of phenoloxidase found in  oyster populations. Native polyacrylamide gel electrophoresis (native-PAGE) identified  five discrete types of phenoloxidase in  non-selected (wild type) and fourth generation  QX disease resistant (QXR4) oysters. One electrophoretically distinct form of  phenoloxidase, POb, is significantly less  frequent in resistant oysters when compared to the wild type population. The frequency of POb also decreased in both the wild type and QXR4 populations over the course of a QX disease outbreak. This suggests that possession of POb makes oysters susceptible to QX disease and that breeding for resistance has resulted in negative selection against this form of phenoloxidase.
Keyword Saccostrea glomerata
Phenoloxidase
QX disease
Marteilia sydneyi
Oysters
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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Created: Mon, 11 Jan 2010, 12:29:41 EST by Simon Utteridge on behalf of Faculty of Science